They still dont have a personality, and theyre waiting for the maturity call. Stem cells in our bone marrow usually develop into blood cells, replenishing our blood system. However, in states of emergency, the destiny of some of these stem cells may change: They can become virtually any type of cell – liver cells, muscle cells, nerve cells – responding to the bodys needs.
Prof. Tsvee Lapidot and Dr. Orit Kollet of the Weizmann Institutes Immunology Department have found how the liver, when damaged, sends a cry for help to these stem cells. "When the liver becomes damaged, it signals to stem cells in the bone marrow, which rush to it and help in its repair – as liver cells," says Lapidot. His research team has found that certain molecules that govern normal development of the liver become overproduced when it is damaged, signaling to the stem cells in the bone marrow to come to the site. The scientists were able to pinpoint the signaling molecules – HGF, MMP-9 and SDF-1– and describe the homing process. HGF is involved in liver cell development and, in irregular cases, can play a role in cancer metastasis. MMP-9 assists cell migration from the blood system into various types of tissue, including liver tissue. SDF-1 is a molecule that stem cells are attracted to. The scientists discovered that large amounts of HGF and MMP-9, when overproduced in the damaged liver, enter the blood flow and increase the sensitivity of stem cells in the bone marrow to SDF-1. Suddenly able to sense SDF-1s calling signal from the liver (which itself is amplified due to increased production and distribution of SDF-1), the stem cells migrate from the bone marrow into the blood and navigate their way to the liver. The findings could lead to new insights into organ repair and transplants, especially liver-related ones. They may also uncover a whole new stock of stem cells that can under certain conditions become liver cells. Until a few years ago only embryonic stem cells were thought to possess such capabilities. Understanding how stem cells in the bone marrow turn into liver cells could one day be a great boon to liver repair as well as an alternative to the use of embryonic stem cells.
Alex Smith | EurekAlert!
Kidney tumor: Genetic trigger discovered
18.06.2018 | Julius-Maximilians-Universität Würzburg
New type of photosynthesis discovered
18.06.2018 | Imperial College London
Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.
Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...
The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.
Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.
An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.
Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...
Light detection and control lies at the heart of many modern device applications, such as smartphone cameras. Using graphene as a light-sensitive material for...
Water molecules exist in two different forms with almost identical physical properties. For the first time, researchers have succeeded in separating the two forms to show that they can exhibit different chemical reactivities. These results were reported by researchers from the University of Basel and their colleagues in Hamburg in the scientific journal Nature Communications.
From a chemical perspective, water is a molecule in which a single oxygen atom is linked to two hydrogen atoms. It is less well known that water exists in two...
13.06.2018 | Event News
08.06.2018 | Event News
05.06.2018 | Event News
18.06.2018 | Earth Sciences
18.06.2018 | Process Engineering
18.06.2018 | Life Sciences