Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Weizmann Institute scienists find that stem cells in the bone marrow become liver cells

12.08.2003


They still don’t have a personality, and they’re waiting for the maturity call. Stem cells in our bone marrow usually develop into blood cells, replenishing our blood system. However, in states of emergency, the destiny of some of these stem cells may change: They can become virtually any type of cell – liver cells, muscle cells, nerve cells – responding to the body’s needs.



Prof. Tsvee Lapidot and Dr. Orit Kollet of the Weizmann Institute’s Immunology Department have found how the liver, when damaged, sends a cry for help to these stem cells. "When the liver becomes damaged, it signals to stem cells in the bone marrow, which rush to it and help in its repair – as liver cells," says Lapidot. His research team has found that certain molecules that govern normal development of the liver become overproduced when it is damaged, signaling to the stem cells in the bone marrow to come to the site. The scientists were able to pinpoint the signaling molecules – HGF, MMP-9 and SDF-1– and describe the homing process. HGF is involved in liver cell development and, in irregular cases, can play a role in cancer metastasis. MMP-9 assists cell migration from the blood system into various types of tissue, including liver tissue. SDF-1 is a molecule that stem cells are attracted to. The scientists discovered that large amounts of HGF and MMP-9, when overproduced in the damaged liver, enter the blood flow and increase the sensitivity of stem cells in the bone marrow to SDF-1. Suddenly able to sense SDF-1’s calling signal from the liver (which itself is amplified due to increased production and distribution of SDF-1), the stem cells migrate from the bone marrow into the blood and navigate their way to the liver. The findings could lead to new insights into organ repair and transplants, especially liver-related ones. They may also uncover a whole new stock of stem cells that can under certain conditions become liver cells. Until a few years ago only embryonic stem cells were thought to possess such capabilities. Understanding how stem cells in the bone marrow turn into liver cells could one day be a great boon to liver repair as well as an alternative to the use of embryonic stem cells.



Prof. Tsvee Lapidot’s research is supported by the Concern Foundation, Beverly Hills, CA; Ms. Rhoda Goldstein, Nanuet, NY; Levine Institute of Applied Science; M.D. Moross Institute for Cancer Research; Ms. Nora Peisner, Hungtington, MI; and Gabrielle Rich Center for Transplantation Biology Research.


Alex Smith | EurekAlert!
Further information:
http://www.weizmann.ac.il/

More articles from Life Sciences:

nachricht Topologische Quantenchemie
21.07.2017 | Max-Planck-Institut für Chemische Physik fester Stoffe

nachricht Topological Quantum Chemistry
21.07.2017 | Max-Planck-Institut für Chemische Physik fester Stoffe

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: 3-D scanning with water

3-D shape acquisition using water displacement as the shape sensor for the reconstruction of complex objects

A global team of computer scientists and engineers have developed an innovative technique that more completely reconstructs challenging 3D objects. An ancient...

Im Focus: Manipulating Electron Spins Without Loss of Information

Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.

For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...

Im Focus: The proton precisely weighted

What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.

To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...

Im Focus: On the way to a biological alternative

A bacterial enzyme enables reactions that open up alternatives to key industrial chemical processes

The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase....

Im Focus: The 1 trillion tonne iceberg

Larsen C Ice Shelf rift finally breaks through

A one trillion tonne iceberg - one of the biggest ever recorded -- has calved away from the Larsen C Ice Shelf in Antarctica, after a rift in the ice,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Closing the Sustainability Circle: Protection of Food with Biobased Materials

21.07.2017 | Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

The technology with a feel for feelings

12.07.2017 | Event News

 
Latest News

Ultrathin device harvests electricity from human motion

24.07.2017 | Power and Electrical Engineering

Scientists announce the quest for high-index materials

24.07.2017 | Materials Sciences

ADIR Project: Lasers Recover Valuable Materials

24.07.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>