Scientists from the Howard Hughes Medical Institute and their colleagues have unraveled some of the fundamental mysteries about the genetic mechanisms that endow the immune system with its life-saving ability to generate specialized antibodies.
Without genetic fine-tuning, antibodies would be relatively ineffective in finding a good match on the surface of viruses, parasites, and other potentially dangerous foreign pathogens. The findings also reveal the workings of a gene mutation process that can go awry, leading to the development of certain forms of cancer or allergic reactions.
HHMI investigator Frederick W. Alt at Children’s Hospital in Boston and Harvard Medical School directed the studies. His team’s findings explain the genetic line dance by which an otherwise generic immunoglobulin, or antibody, molecule acquires the genetic components that encode for the structural characteristics it needs to activate appropriate pathways to eliminate specific types of invaders, or antigens. The appropriate class of immunoglobulin can then mark invading cells for elimination by other cells of the immune system.
Jim Keeley | Howard Hughes Medical Institute
'Lipid asymmetry' plays key role in activating immune cells
20.02.2018 | Biophysical Society
New printing technique uses cells and molecules to recreate biological structures
20.02.2018 | Queen Mary University of London
For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.
In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.
But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...
Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.
The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...
Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters
Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...
15.02.2018 | Event News
13.02.2018 | Event News
12.02.2018 | Event News
20.02.2018 | Life Sciences
20.02.2018 | Medical Engineering
20.02.2018 | Physics and Astronomy