Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Research reveals how strep bacterium evades immune system

28.01.2003


Like a well-trained soldier with honed survival skills, the common bacterium, Group A Streptococcus (GAS), sometimes can endure battle with our inborn (innate) immune system and cause widespread disease. By investigating the ability of combat-ready white blood cells (WBCs) to ingest and kill GAS, researchers have discovered new insights into how this disease-causing bacteria can evade destruction by the immune system. The research is being published this week in the Online Early Edition of the Proceedings of the National Academy of Sciences,USA at http://www.pnas.org/papbyrecent.shtml.



Frank DeLeo, Ph.D., tenure-track investigator in the Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases (NIAID), Rocky Mountain Laboratories in Hamilton, MT, directed the study. "This is the first genome-scale look at GAS genes that are differentially expressed during interaction with the human innate immune system," he says. "We are excited about our findings and how they may lead to further investigation of therapeutics that can protect us from this major human pathogen." According to Dr. DeLeo, this type of study is the next logical application of microbial genomics.

An estimated 15 million new cases of noninvasive GAS infections occur in the United States each year, with a direct health care cost of $2 billion. The noninvasive and milder types of infection, primarily strep throat and skin infections, occur mostly in children between the ages of 5 and 14 years old. Elementary school-aged children are at highest risk for noninvasive disease. In 2000, the reported incidence of the more serious invasive GAS disease, which includes streptococcal toxic shock syndrome (STSS), cellulitis, pneumonia, bacteremia and necrotizing fasciitis (flesh-eating disease), was 8,800 cases and 1,000 deaths. The elderly, immunosuppressed, persons with chronic cardiac or respiratory disease or diabetes, African Americans, American Indians and persons with skin lesions (for example, children with chickenpox and intravenous drug users) have increased risk for GAS invasive disease.


Some GAS infections may be asymptomatic, and if untreated, can lead to life-threatening infections. With an early diagnosis, however, noninvasive GAS can be successfully treated with antibiotics. On the other hand, it is much more difficult to treat invasive GAS disease, and these infections are associated with high morbidity and mortality.

By examining the interaction between disease-fighting human WBCs and a type of GAS that causes abundant disease in North America and Western Europe, the NIAID scientists have discovered how GAS elicits its own genome-wide protective response to evade destruction by the human immune system. The two opponents, WBCs and GAS, met face to face in experiments conducted by Dr. DeLeo, James Musser, M.D., Ph.D., chief of the Laboratory of Human Bacterial Pathogenesis, and their colleagues.

For their study, the researchers used human WBCs called polymorphonuclear leukocytes (PMNs), an essential component of the immune system’s defense against foreign invaders. These microbe-eating cells are in a class of cells termed phagocytes, which stand ready to seek and destroy foreign substances such as bacteria. During battle with most foreign microbes, PMNs successfully "eat" invading predators, a scientific process called phagocytosis. After microbes are engulfed, PMNs produce deadly oxygen radicals, such as hydrogen peroxide and hypoclorous acid (the active ingredient in household bleach), and release toxic granules to kill the enemy. Normally, this defense tactic can defeat most foreign invaders, but it is ineffective against highly evolved GAS bacterium.

The scientists examined how PMNs from healthy individuals ingest and kill GAS and tested their hypothesis that GAS revs up or slows down the production of specific factors to evade the innate immune system. The study indicates that GAS becomes more resilient to ingestion and killing by PMNs over time or it produces factors that alter normal PMN function. This resiliency is demonstrated by the increased expression of various GAS genes associated with the bacteria’s virulence and cell wall repair as well as genes that encode proteins likely to promote immune evasion.

The study’s lead author, Jovanka Voyich, Ph.D., states, "Our study identifies potential vaccine candidates and new targets for therapy interventions designed to control GAS infections."

The scientists hope that this new knowledge in combination with their earlier GAS research will lead to further investigation of how GAS evades destruction by our innate immune system and will inevitably spur the discovery of vaccine therapies and antibiotics that can prevent and treat invasive and noninvasive strains of this bacterium.


NIAID is a component of the National Institutes of Health (NIH), an agency of the Department of Health and Human Services. NIAID supports basic and applied research to prevent, diagnose, and treat infectious and immune-mediated illnesses, including HIV/AIDS and other sexually transmitted diseases, illness from potential agents of bioterrorism, tuberculosis, malaria, autoimmune disorders, asthma and allergies.

Walter Mitton | EurekAlert!
Further information:
http://www.pnas.org/papbyrecent.shtml

More articles from Life Sciences:

nachricht The interactome of infected neural cells reveals new therapeutic targets for Zika
23.01.2017 | D'Or Institute for Research and Education

nachricht Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery
20.01.2017 | GSI Helmholtzzentrum für Schwerionenforschung GmbH

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

The interactome of infected neural cells reveals new therapeutic targets for Zika

23.01.2017 | Life Sciences

Melting solid below the freezing point

23.01.2017 | Materials Sciences

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

VideoLinks
B2B-VideoLinks
More VideoLinks >>>