In a discovery with implications for treatment of anxiety disorders, UCLA Neuropsychiatric Institute investigators have identified a distinct molecular process in the brain involved in overcoming fear. The findings will be published in the Oct. 15 edition of the Journal of Neuroscience.
The study of how mice acquire, express and extinguish conditional fear shows for the first time that L-type voltage-gated calcium channels (LVGCCs) -- one of hundreds of varieties of electrical switches found in brain cells -- are required to overcome fear but play no role in becoming fearful or expressing fear. The findings suggest that it may be possible to identify the cells, synapses and molecular pathways specific to extinguishing fear, and to the treatment of human anxiety disorders.
"Brain plasticity, or the ability of the central nervous system to modify cellular connections, has long been recognized as a key component to learning and memory," said Dr. Mark Barad, the UCLA Neuropsychiatric Institutes Tennenbaum Family Center faculty scholar and an assistant professor in-residence of psychiatry at the David Geffen School of Medicine at UCLA. "The discovery of a distinct molecular process in overcoming fear bodes well for development of new drugs that can make psychotherapy, or talk therapy, easier and more effective in treating anxiety disorders. More broadly, the findings also suggest that distinct molecular processes may be involved in the expression and treatment of other psychiatric disorders."
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The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
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In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
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