Discovery could lead to the identification of other cancer-preventing compounds
Using gene chip technology, researchers at the Johns Hopkins Bloomberg School of Public Health have identified the blueprint of genes and enzymes in the body that enable sulforaphane, a compound found in broccoli and other vegetables, to prevent cancer and remove toxins from cells. The discovery was made using a "gene chip" that allows researchers to monitor the complex interactions of thousands of proteins on a whole genome rather than one at time. The study is published in the September 15, 2002 issue of the journal Cancer Research, and is the first gene profiling analysis of a cancer-preventing agent using this approach. The researchers believe the findings provide a better understanding of the bodys defense mechanisms and could lead to the identification of other cancer-preventing food compounds and strategies.
For the study, the researchers analyzed the downstream genomic targets of the transcription factor Nrf2 (Nuclear factor E2 p45-related factor 2), which scientists previously knew was activated in response to anticancer agents such as sulforaphane. The transcription factor, Nrf2, in response to cancer preventive agents, turns on genes and pathways inside the cell, whose products help in ridding the body of carcinogens.
Single-stranded DNA and RNA origami go live
15.12.2017 | Wyss Institute for Biologically Inspired Engineering at Harvard
New antbird species discovered in Peru by LSU ornithologists
15.12.2017 | Louisiana State University
DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.
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MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.
Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...
Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
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