Scientists have identified a key regulatory mechanism in the TGF-ß pathway. This discovery by Dr. Kai Lin and colleagues at UMASS Medical School and the University of Mississippi Medical Center helps further our understanding of how this important signaling pathway functions in a variety of cellular processes, including cancer formation and embryonic development.
The work is published in the August 1 issue of Genes & Development.
The TGF-ß pathway is an intracellular signaling pathway that enables a cell to respond to changes in its environment. This signal transduction pathway converts ligand binding at the cell surface into an enzymatic cascade inside the cell, which ultimately induces changes in gene expression. In this fashion, the TGF-ß pathway regulates a number of different cellular responses, including cell proliferation, differentiation and migration, programmed cell death, and development.
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