Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

How inflammatory proteins can protect against cancer

13.06.2008
Our body has a better way of protecting itself against cancer than previously recognised. Inflammatory proteins help to prevent the progression of a benign tumour to a malignant one.

This is reported by Dr. Daniel Peeper and his colleagues from the Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital (NKI-AVL) in the June 13 issue of the prominent scientific journal Cell.

The cells in our body are exposed to numerous factors that can inflict damage to the genetic material (DNA). Usually, these errors are repaired. Sometimes, however, a change is incorporated into the DNA. If such a mutation localises to a so-called oncogene, a cell can be stimulated to divide, and a benign tumour can arise. Previously, the research group of Dr. Peeper showed that this does not necessarily result in the generation of a malignant tumour. They discovered that benign tumours can activate a permanent growth arrest, such that they enter a hibernation-like state (Nature, Aug 4th 2005). This hibernation represents a natural barrier against cancer.

In the present follow-up study, Thomas Kuilman, a PhD student in Dr. Peeper’s research laboratory, delineated the mechanism behind this hibernation in benign tumours. He compared the activity of thousands of genes in dividing and dormant tumour cells and discovered a specific DNA fingerprint. Unexpectedly, this revealed that in non-dividing tumour cells, dozens of genes that normally play a role in inflammatory reactions of the body, are activated.

... more about:
»benign »inflammatory

In collaboration with Dr. Lucien Aarden (Sanquin), the researchers subsequently used advanced techniques to show that inflammatory proteins are essential to keep benign tumour cells in a non-proliferating state. Finally, together with Dr. Wolter Mooi (VUmc) the researchers showed that these inflammatory proteins are likely to play an important role in the natural defence against colon cancer.

Frederique Melman | alfa
Further information:
http://www.nki.nl

Further reports about: benign inflammatory

More articles from Life Sciences:

nachricht Researchers identify potentially druggable mutant p53 proteins that promote cancer growth
09.12.2016 | Cold Spring Harbor Laboratory

nachricht Plant-based substance boosts eyelash growth
09.12.2016 | Fraunhofer-Institut für Angewandte Polymerforschung IAP

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>