Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

How inflammatory proteins can protect against cancer

13.06.2008
Our body has a better way of protecting itself against cancer than previously recognised. Inflammatory proteins help to prevent the progression of a benign tumour to a malignant one.

This is reported by Dr. Daniel Peeper and his colleagues from the Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital (NKI-AVL) in the June 13 issue of the prominent scientific journal Cell.

The cells in our body are exposed to numerous factors that can inflict damage to the genetic material (DNA). Usually, these errors are repaired. Sometimes, however, a change is incorporated into the DNA. If such a mutation localises to a so-called oncogene, a cell can be stimulated to divide, and a benign tumour can arise. Previously, the research group of Dr. Peeper showed that this does not necessarily result in the generation of a malignant tumour. They discovered that benign tumours can activate a permanent growth arrest, such that they enter a hibernation-like state (Nature, Aug 4th 2005). This hibernation represents a natural barrier against cancer.

In the present follow-up study, Thomas Kuilman, a PhD student in Dr. Peeper’s research laboratory, delineated the mechanism behind this hibernation in benign tumours. He compared the activity of thousands of genes in dividing and dormant tumour cells and discovered a specific DNA fingerprint. Unexpectedly, this revealed that in non-dividing tumour cells, dozens of genes that normally play a role in inflammatory reactions of the body, are activated.

... more about:
»benign »inflammatory

In collaboration with Dr. Lucien Aarden (Sanquin), the researchers subsequently used advanced techniques to show that inflammatory proteins are essential to keep benign tumour cells in a non-proliferating state. Finally, together with Dr. Wolter Mooi (VUmc) the researchers showed that these inflammatory proteins are likely to play an important role in the natural defence against colon cancer.

Frederique Melman | alfa
Further information:
http://www.nki.nl

Further reports about: benign inflammatory

More articles from Life Sciences:

nachricht Cancer diagnosis: no more needles?
25.05.2018 | Christian-Albrechts-Universität zu Kiel

nachricht Less is more? Gene switch for healthy aging found
25.05.2018 | Leibniz-Institut für Alternsforschung - Fritz-Lipmann-Institut e.V. (FLI)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Powerful IT security for the car of the future – research alliance develops new approaches

The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.

Vehicles already offer diverse communication interfaces and more and more automated functions, such as distance and lane-keeping assist systems. At the same...

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

In focus: Climate adapted plants

25.05.2018 | Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

 
Latest News

In focus: Climate adapted plants

25.05.2018 | Event News

Flow probes from the 3D printer

25.05.2018 | Machine Engineering

Less is more? Gene switch for healthy aging found

25.05.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>