This is reported by Dr. Daniel Peeper and his colleagues from the Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital (NKI-AVL) in the June 13 issue of the prominent scientific journal Cell.
The cells in our body are exposed to numerous factors that can inflict damage to the genetic material (DNA). Usually, these errors are repaired. Sometimes, however, a change is incorporated into the DNA. If such a mutation localises to a so-called oncogene, a cell can be stimulated to divide, and a benign tumour can arise. Previously, the research group of Dr. Peeper showed that this does not necessarily result in the generation of a malignant tumour. They discovered that benign tumours can activate a permanent growth arrest, such that they enter a hibernation-like state (Nature, Aug 4th 2005). This hibernation represents a natural barrier against cancer.
In the present follow-up study, Thomas Kuilman, a PhD student in Dr. Peeper’s research laboratory, delineated the mechanism behind this hibernation in benign tumours. He compared the activity of thousands of genes in dividing and dormant tumour cells and discovered a specific DNA fingerprint. Unexpectedly, this revealed that in non-dividing tumour cells, dozens of genes that normally play a role in inflammatory reactions of the body, are activated.
In collaboration with Dr. Lucien Aarden (Sanquin), the researchers subsequently used advanced techniques to show that inflammatory proteins are essential to keep benign tumour cells in a non-proliferating state. Finally, together with Dr. Wolter Mooi (VUmc) the researchers showed that these inflammatory proteins are likely to play an important role in the natural defence against colon cancer.
Frederique Melman | alfa
At last, butterflies get a bigger, better evolutionary tree
16.02.2018 | Florida Museum of Natural History
New treatment strategies for chronic kidney disease from the animal kingdom
16.02.2018 | Veterinärmedizinische Universität Wien
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.
But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...
Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.
The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...
Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters
Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...
Let’s say the armrest is broken in your vintage car. As things stand, you would need a lot of luck and persistence to find the right spare part. But in the world of Industrie 4.0 and production with batch sizes of one, you can simply scan the armrest and print it out. This is made possible by the first ever 3D scanner capable of working autonomously and in real time. The autonomous scanning system will be on display at the Hannover Messe Preview on February 6 and at the Hannover Messe proper from April 23 to 27, 2018 (Hall 6, Booth A30).
Part of the charm of vintage cars is that they stopped making them long ago, so it is special when you do see one out on the roads. If something breaks or...
15.02.2018 | Event News
13.02.2018 | Event News
12.02.2018 | Event News
16.02.2018 | Information Technology
16.02.2018 | Health and Medicine
16.02.2018 | Physics and Astronomy