Until now it is strongly believed that the immune system controls growth of tumors by killing tumor cells. The Tubingen researchers, members of the Comprehensive Cancer Center, now show that immune responses can prevent tumor growth without killing tumor cells.
They used a model of endogenously growing tumors that develop, like many human tumors, because of a defect in normal cell death. The researchers show that the immune system can prevent tumor growth without destroying tumor cells. They show that early treatment of developing tumors arrests tumor development at very early stages through a strictly cytokine mediated mechanism. One of the important players that prevents the outgrowth of malignant tumors is interferon.
The researchers show further a second important aspect: Immune responses can both - either induce tumor dormancy or, unexpectedly, tumor growth. In the absence of either interferon or tumor necrosis factor the immune response converts the from a protective into a tumor promoting immune response.
In conclusion, the paper gives a great hope and new aspects for the development of new tumor vaccines. They show that tumor immune responses can induce tumor dormancy, which means that the immune response arrests tumors at early stages. Yet, these immune responses have to occur early in tumor development and have to provide the correct pattern of cytokines. In the case of an inappropriate cytokine pattern, i.e. missing interferon or missing tumor necrosis factor, the same response may dramatically enhance tumor growth.Prof. Dr. Martin Röcken, MD
Dr. Ellen Katz | idw
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24.04.2017 | Indiana University
Two-dimensional melting of hard spheres experimentally unravelled after 60 years
24.04.2017 | University of Oxford
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
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