Until now it is strongly believed that the immune system controls growth of tumors by killing tumor cells. The Tubingen researchers, members of the Comprehensive Cancer Center, now show that immune responses can prevent tumor growth without killing tumor cells.
They used a model of endogenously growing tumors that develop, like many human tumors, because of a defect in normal cell death. The researchers show that the immune system can prevent tumor growth without destroying tumor cells. They show that early treatment of developing tumors arrests tumor development at very early stages through a strictly cytokine mediated mechanism. One of the important players that prevents the outgrowth of malignant tumors is interferon.
The researchers show further a second important aspect: Immune responses can both - either induce tumor dormancy or, unexpectedly, tumor growth. In the absence of either interferon or tumor necrosis factor the immune response converts the from a protective into a tumor promoting immune response.
In conclusion, the paper gives a great hope and new aspects for the development of new tumor vaccines. They show that tumor immune responses can induce tumor dormancy, which means that the immune response arrests tumors at early stages. Yet, these immune responses have to occur early in tumor development and have to provide the correct pattern of cytokines. In the case of an inappropriate cytokine pattern, i.e. missing interferon or missing tumor necrosis factor, the same response may dramatically enhance tumor growth.Prof. Dr. Martin Röcken, MD
Dr. Ellen Katz | idw
Cryo-electron microscopy achieves unprecedented resolution using new computational methods
24.03.2017 | DOE/Lawrence Berkeley National Laboratory
How cheetahs stay fit and healthy
24.03.2017 | Forschungsverbund Berlin e.V.
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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24.03.2017 | Physics and Astronomy