Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Scientists at Yale provide explanation for how cancer spreads

02.05.2008
Metastasis, the spread of cancer throughout the body, can be explained by the fusion of a cancer cell with a white blood cell in the original tumor, according to Yale School of Medicine researchers, who say that this single event can set the stage for cancer’s migration to other parts of the body.

Their work was Published in the May issue of Nature Reviews Cancer. The studies, spanning 15 years, have revealed that the newly formed hybrid of the cancer cell and white blood cell adapts the white blood cell’s natural ability to migrate around the body, while going through the uncontrolled cell division of the original cancer cell. This causes a metastatic cell to emerge, which like a white blood cell, can migrate through tissue, enter the circulatory system and travel to other organs.

“This is a unifying explanation for metastasis,” said John Pawelek, a researcher in the Department of Dermatology at Yale School of Medicine and at Yale Cancer Center, who conducted the studies with colleague Ashok K. Chakraborty and several other Yale scientists. “Although we know a vast amount about cancer, how a cancer cell becomes metastatic still remains a mystery.”

The fusion theory was first proposed in the early 1900s and has attracted a lot of scientific interest over the years. Pawelek and his colleagues began their research several years ago by fusing white blood cells with tumor cells. These experimental hybrids the researchers observed, were remarkably metastatic and lethal when implanted into mice. In addition, the scientists noted, some of the molecules the hybrids used to metastasize originated from white blood cells, and these molecules were the same as those used by metastatic cells in human cancers. Pawelek and his team then validated previous findings that hybridization occurs naturally in mice, and results in metastatic cancer.

... more about:
»HYBRID »Pawelek »blood »blood cells »metastasis »metastatic

“Viewing the fusion of a cancer cell and a white blood cell as the initiating event for metastasis suggests that metastasis is virtually another disease imposed on the pre-existing cancer cell,” said Pawelek. “We expect this to open new areas for therapy based on the fusion process itself.”

The research team recently began studying cancers from individuals who had received a bone marrow transplant—a new source of white blood cells for the patient. Genes from the transplanted white blood cells were found in the patient tumor cells, indicating that fusion with white blood cells had occurred. But Pawelek said these studies must be greatly expanded before his team can say with certainty that white blood cell fusion accounts for cancer metastasis in humans.

“To date, the fusion theory and the considerable evidence supporting it have largely been overlooked by the cancer research community,” said Pawelek. “The motivation for our article is to encourage other laboratories to join in.”

Karen N. Peart | EurekAlert!
Further information:
http://www.yale.edu

Further reports about: HYBRID Pawelek blood blood cells metastasis metastatic

More articles from Life Sciences:

nachricht Cancer diagnosis: no more needles?
25.05.2018 | Christian-Albrechts-Universität zu Kiel

nachricht Less is more? Gene switch for healthy aging found
25.05.2018 | Leibniz-Institut für Alternsforschung - Fritz-Lipmann-Institut e.V. (FLI)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Powerful IT security for the car of the future – research alliance develops new approaches

The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.

Vehicles already offer diverse communication interfaces and more and more automated functions, such as distance and lane-keeping assist systems. At the same...

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

In focus: Climate adapted plants

25.05.2018 | Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

 
Latest News

In focus: Climate adapted plants

25.05.2018 | Event News

Flow probes from the 3D printer

25.05.2018 | Machine Engineering

Less is more? Gene switch for healthy aging found

25.05.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>