Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New Tool Scans the Genome for Disease-relevant Variations

29.04.2008
Investigating the genetic background of major diseases has now become easier. As part of a European-Japanese Consortium (STAR), Dr. Kathrin Saar and Prof. Norbert Hübner from the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch, Germany, have constructed a genome map with more than 300 different rat strains.

The researchers are convinced that this new tool can help understand the development of cardiovascular diseases or diabetes in laboratory rats as well as in humans. The paper of the STAR consortium has been published online in the current issue of the journal Nature Genetics* (Vol. 40, No. 5, pp. 560 - 566, 2008).

Laboratory rats are particularly suited for analyzing the genetic causes of epidemiological-relevant diseases. For over 150 years, scientists have been using laboratory rats as model animals in clinical research laboratories. It is known that the DNA sequence of every organism shows natural variations called "single nucleotide polymorphisms" or SNPs. Typically, the genome of an individual has several million SNPs and, thus, he or she differs at this level from others within the same species. Scientists investigate these SNPs to clarify whether they are linked to or influence the development of certain diseases. The MDC researchers and their colleagues in Europe and Japan have now identified three million SNPs in the genome of the rat. Thus, they were able to expand and improve upon the existing genomic map which until now was based on the analyses of only three rat strains.

SNP and haplotype mapping for genetic analysis in the rat
The STAR Consortium1
The complete list of authors is as follows:
The STAR Consortium: Kathrin Saar1, Alfred Beck2, Marie-Thérèse Bihoreau3, Ewan Birney4, Denise Brocklebank3, Yuan Chen4, Edwin Cuppen5, Stephanie Demonchy6, Paul Flicek4, Mario Foglio6, Asao Fujiyama7,8, Ivo G. Gut6, Dominique Gauguier3, Roderic Guigo9, Victor Guryev5, Matthias Heinig1, Oliver Hummel1, Niels Jahn10, Sven Klages2, Vladimir Kren11, Heiner Kuhl2, Takashi Kuramoto12, Yoko Kuroki7, Doris Lechner6, Young-Ae Lee1, Nuria Lopez-Bigas9, G. Mark Lathrop6, Tomoji Mashimo12, Michael Kube2, Richard Mott3, Giannino Patone1, Jeanne-Antide Perrier-Cornet6, Matthias Platzer10, Michal Pravenec11, Richard Reinhardt2, Yoshiyuki Sakaki7, Markus Schilhabel10, Herbert Schulz1, Tadao Serikawa12, Medya Shikhagaie9, Shouji Tatsumoto7, Stefan Taudien10, Atsushi Toyoda7, Birger Voigt12, Diana Zelenika6, Heike Zimdahl1 & Norbert Hübner1
... more about:
»Molecular »SNP »STAR

1Max-Delbrück-Center for Molecular Medicine (MDC), Robert-Roessle-Strasse 10, 13125, Berlin, Germany. 2Max Planck Institute for Molecular Genetics, Berlin, Germany. 3Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. 4European Bioinformatics Institute, Hinxton, UK. 5Hubrecht Institute, Utrecht, The Netherlands. 6CEA/Institut de Génomique, Centre National de Génotypage, Evry, France. 7RIKEN Genomic Sciences Center, Kanagawa 230-0045, Japan. 8National Institute of Informatics, Tokyo 101-8430, Japan. 9Centre de Regulacio Genomica, Barcelona, Spain. 10Leibniz-Institut für Altersforschung - Fritz-Lipmann-Institut, Jena, Germany. 11Institute of Physiology, Czech Academy of Sciences and 1st Medical Faculty, Charles University, Prague, Czech Republic. 12Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.

Barbara Bachtler
Press and Public Affairs
Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch
Robert-Rössle-Straße 10; 13125 Berlin; Germany
Phone: +49 (0) 30 94 06 - 38 96
Fax: +49 (0) 30 94 06 - 38 33
e-mail: presse@mdc-berlin.de

Barbara Bachtler | Max-Delbrück-Centrum
Further information:
http://www.mdc-berlin.de/en/news
http://www.mdc-berlin.de/en/news/2004/20040206-variations_in_the_genome/index.html

Further reports about: Molecular SNP STAR

More articles from Life Sciences:

nachricht The interactome of infected neural cells reveals new therapeutic targets for Zika
23.01.2017 | D'Or Institute for Research and Education

nachricht Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery
20.01.2017 | GSI Helmholtzzentrum für Schwerionenforschung GmbH

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>