Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Mitochondria play role in pathogenesis of AD and estrogen-induced neuroprotection

08.04.2008
As the major source of free radicals in cells, mitochondria contribute to the high levels of oxidative stress believed to play a role in the pathogenesis of Alzheimer’s disease.

Now, a new study from the laboratory of Dr. Roberta Brinton, University of Southern California, demonstrates that estrogen reduces this oxidative stress caused by the mitochondria while increasing the ability of the mitochondria to generate energy – important since there is usually an energy deficit in the Alzheimer brain.

The study was presented April 5 at Experimental Biology 2008 in San Diego by Jia Yao, a graduate student in Dr. Brinton’s laboratory. The presentation is part of the scientific program of the American Association of Anatomists (AAA), and Mr. Yao’s presentation is a finalist for the AAA Langman Graduate Studet Platform Presentation Award. He also received an AAA travel award.

Mitochondria, small organelles within the cells, use a process called Oxidative Phosphorylation to generate the vast majority of the adenosine triposphate (ATP) molecules that cells utilize to function properly. If the mitochondria become less efficient with age or disease, they use less up oxygen during this process. This inefficiency produces a double hit against the brain: fewer energy molecules being produced and more free radicals being released, leading to damaging oxidative stress.

Using a combination of biochemical and proteomic (protein) approaches, Dr. Brinton’s research team demonstrated how estrogen acts to regulate mitochondrial function in ways pivotal for protection against Alzheimer’s disease. These include:

an increase of mitochondrial efficiency, enhancing the organelles’ ability to generate energy-laden ATP molecules needed by the brain;

increased expression of key proteins required for ATP generation;

reduction of oxidative stress, protecting neurons from oxidative damage;

prevention of excess apoptosis, or programmed cell death, of neurons of the brain;

and protection of neurons from mitochondrial toxins, which can induce further mitochondrial dysfunction and cell death.

Dr. Brinton and her research team currently are validating the energy-production levels of mitochondria as a biomarker that could detect the presence of Alzheimer’s in the earliest stages, when the neurodegenerative process might be stopped or slowed or therapeutics be more effective. They believe this new information on how estrogen regulates mitochondrial function also sheds light on how to develop a new generation of effective Alzheimer therapeutics. Dr. Brinton currently is developing new, brain specific molecules that promote neurological defense against Alzheimer’s, using similar mechanisms as estrogen, but without estrogen’s negative side effects.

Sylvia Wrobel | EurekAlert!
Further information:
http://www.faseb.org

Further reports about: Alzheimer Estrogen Oxidative mitochondria mitochondrial

More articles from Life Sciences:

nachricht One step closer to reality
20.04.2018 | Max-Planck-Institut für Entwicklungsbiologie

nachricht The dark side of cichlid fish: from cannibal to caregiver
20.04.2018 | Veterinärmedizinische Universität Wien

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Spider silk key to new bone-fixing composite

University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.

Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.

Im Focus: Writing and deleting magnets with lasers

Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.

Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...

Im Focus: Gamma-ray flashes from plasma filaments

Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.

The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...

Im Focus: Basel researchers succeed in cultivating cartilage from stem cells

Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.

Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...

Im Focus: Like a wedge in a hinge

Researchers lay groundwork to tailor drugs for new targets in cancer therapy

In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

IWOLIA: A conference bringing together German Industrie 4.0 and French Industrie du Futur

09.04.2018 | Event News

 
Latest News

Magnetic nano-imaging on a table top

20.04.2018 | Physics and Astronomy

Start of work for the world's largest electric truck

20.04.2018 | Interdisciplinary Research

Atoms may hum a tune from grand cosmic symphony

20.04.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>