Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Running out of treatments: The problem superbugs resistant to everything

02.04.2008
Doctors are running out of treatments for today’s trauma victims and critically ill patients because of infections due to drug resistant microbes – even after resorting to using medicines thrown out 20 years ago because of severe side effects, scientists heard today (Tuesday 1 April 2008) at the Society for General Microbiology’s 162nd meeting being held this week at the Edinburgh International Conference Centre.

“Doctors in many countries have gone back to using old antibiotics that were abandoned 20 years ago because their toxic side effects were so frequent and so bad”, says Professor Matthew Falagas from the Alfa Institute of Biomedical Sciences in Athens, Greece and Tufts University School of Medicine, Boston, Massachusetts. “But superbugs like Acinetobacter have challenged doctors all over the world by now becoming resistant to these older and considered more dangerous medicines”.

“Even colistin, a polymyxin type antibiotic discovered 60 years ago, has recently been used as a salvage remedy to treat patients with Acinetobacter infections”, says Professor Falagas. “And it was successful for a while, but now it occasionally fails due to recent extensive use that has caused the bacteria to become resistant, leading to problem superbugs which are pan-drug resistant, in other words resistant to all available antibiotics”.

The Greek researchers have also shown in new data analyses that Acinetobacter is a more serious threat than previously thought – it doesn’t just cause severe infections, it kills many more patients than doctors had realised. Acinetobacter can cause pneumonia, skin and wound infections and in some cases meningitis.

The scientists have also identified a whole range of drug resistant strategies being used by the bacteria, including the production of compounds which can inactivate the drug treatments, cell pumps that can bail out the drug molecules from inside bacterial cells making them ineffective, and mutating the drug target sites making the drug molecules miss or fail to latch onto the specific regions of the bacterial cells that they were aiming for.

“There have already been severe problems with critically ill patients due to Acinetobacter baumannii infections in various countries”, says Matthew Falagas. “In some cases we have simply run out of treatments and we could be facing a pandemic with important public health implications”.

Lucy Goodchild | EurekAlert!
Further information:
http://www.sgm.ac.uk

Further reports about: Acinetobacter resistant superbugs treatments

More articles from Life Sciences:

nachricht Immune Defense Without Collateral Damage
23.01.2017 | Universität Basel

nachricht The interactome of infected neural cells reveals new therapeutic targets for Zika
23.01.2017 | D'Or Institute for Research and Education

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Quantum optical sensor for the first time tested in space – with a laser system from Berlin

For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.

According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Tracking movement of immune cells identifies key first steps in inflammatory arthritis

23.01.2017 | Health and Medicine

Electrocatalysis can advance green transition

23.01.2017 | Physics and Astronomy

New technology for mass-production of complex molded composite components

23.01.2017 | Process Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>