Until now, we have not had any specific treatment for the often fatal effects of heat stroke. A group of researchers from the Institut Municipal d'Investigació Mèdica (IMIM-Hospital del Mar), in collaboration with researchers from the Centro Regional de Hemodonación and the General Surgery Service of the University Hospital Virgen de la Arrixaca in Murcia, have just published the results of an experimental project that could mean an important advance in the protection against the effects of heat stroke in the journal Critical Care Medicine.
Heat stroke is defined as an increase in body temperature to above 40 ºC followed by hypothermia (drop in temperature) that is a direct result of an elevated ambient temperature. When a person has heat stroke, his/her body reacts in a similar way as it would for a general inflammation caused by a systemic infection, for example. The person's body temperature rises, producing a systemic inflammation and disseminated intravascular coagulation, which leads to the failure of multiple organs, which in many cases leads to death.
The main finding of the research carried out was the identification of a protein, PARP-1 (poly ADP-ribose polymerase), in the physiopathology of heat stroke. The researchers subjected two groups of mice to a temperature of 42 ºC for a period of 45 minutes. One group of normal mice served as the control, while the other group of mice was inoculated with a PARP-1 inhibitor. The body temperature of both groups was then measured, as well as inflammatory markers and protein levels. With this, the researchers were able to show for the first time that the inhibition of the action of this protein produces a higher tolerance to ambient heat, capable of attenuating the effects of heat stroke and thus at the same time capable of diminishing the mortality associated with this cause.
All signs point towards the temperature on Earth increasing due to global warming. High-temperature situations, such as those experienced in 2003, could be repeated in the future. On that occasion, there were between 22,000 and 45,000 deaths throughout Europe in a single week that were related in varying degrees to the unusual increase in ambient temperature. The temperature increase withstood that summer affected mortality rates in the city of Barcelona, with some 400 deaths being related to the increase in ambient temperature. This increase in mortality primarily affected people older than 70 years.
The results of this research open an important door to the research towards a promising therapeutic method, which has not existed until now, but which is basic for those people threatened by a sudden increase in ambient temperature.
Poly(ADP-ribose) polymerase-1 inhibition increases expression of heat shock proteins and attenuates heat stroke-induced liver injury.Crit Care Med 2008 Vol. 36, Number 2
Javier Corral and Vicente Vicente. Department of Medicine at the Centro Regional de Hemodonación in Murcia.
Pascual Parrilla and Rubén Mota. Surgery Service of the Hospital Virgen de la Arrixaca in Murcia.
Marta Calsina | alfa
Rochester scientists discover gene controlling genetic recombination rates
23.04.2018 | University of Rochester
One step closer to reality
20.04.2018 | Max-Planck-Institut für Entwicklungsbiologie
Physicists at the Laboratory for Attosecond Physics, which is jointly run by Ludwig-Maximilians-Universität and the Max Planck Institute of Quantum Optics, have developed a high-power laser system that generates ultrashort pulses of light covering a large share of the mid-infrared spectrum. The researchers envisage a wide range of applications for the technology – in the early diagnosis of cancer, for instance.
Molecules are the building blocks of life. Like all other organisms, we are made of them. They control our biorhythm, and they can also reflect our state of...
University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.
Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.
Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.
Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...
Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.
The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...
Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.
Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...
13.04.2018 | Event News
12.04.2018 | Event News
09.04.2018 | Event News
23.04.2018 | Physics and Astronomy
23.04.2018 | Physics and Astronomy
23.04.2018 | Trade Fair News