Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A major step toward a more targeted treatment for auto-immune diseases?

28.01.2008
More and more people in Western society are suffering from auto-immune diseases. Discovering the cause of these chronic inflammations is a first important step in the search for targeted medicines.

VIB researchers connected to Ghent University and the Katholieke Universiteit Leuven joined forces and have elucidated the function of MALT1, a key player in controlling inflammatory reactions. They are the first to show that MALT1 is able to cleave the A20 protein, which inhibits inflammation. Scientists hope that by counteracting MALT1 they will be able to restore the body’s natural inhibition of inflammation and thus provide an alternative for treatments that tax the immune system. This would represent a profound improvement over current medicines. Their research will be published in the authoritative journal Nature Immunology.

Raging out of control?

Inflammations are our normal protective reactions against infections - they arise to help remove pathogenic organisms from our bodies. This immune response is very precise and is only possible after a complex cascade of signals. Sometimes something goes wrong in this chain of reactions, and the inflammation process becomes uncontrolled or even triggers undesired immune responses against the body’s own substances. This can lead to auto-immune diseases such as rheumatism, Crohn’s disease, psoriasis, and multiple sclerosis, and, in some cases, to cancer. Reining in the runaway immune system is the most obvious remedy for these kinds of diseases. But the major challenge is to do this in such a way that the immune system continues to perform its protective role. And this requires a thorough understanding of the entire process.

Proteins with a crucial function

It has long been known that the MALT1 protein plays an important role in initiating inflammation reactions. That’s why VIB researchers Beatrice Coornaert (UGent), Rudi Beyaert (UGent), Thijs Baens (K.U.Leuven) and Peter Marynen (K.U.Leuven) set out to discover exactly what its particular role is. They have now succeeded in showing that MALT1 cuts the A20 protein into pieces. They are in fact the first to find that MALT1 is a protease (a protein that cleaves other proteins) and that A20 is the protein that is cut. In normal circumstances, A20 inhibits inflammatory reactions; and, by cleaving A20, MALT1 counteracts this inhibition, allowing the inflammation to progress freely. So, both proteins play very important parts in fine-tuning the intensity of inflammatory reactions.

Prospects for new treatments

Through their research, the VIB scientists are shedding light on an important part of the process that controls our immune response. Their findings offer possibilities for the development of new medicines that counteract MALT1 and thereby restore the natural ‘brake’ on the inflammation process. In this way, scientists hope to be able to provide an alternative for treatments that undermine the immune system. In addition, they hope to be able to apply this knowledge to the typical immunoreactions toward organ transplants or the treatment of cancer that is caused by genetic defects in MALT1, such as MALT lymphoma.

Joining forces

This research clearly shows the added value of combining expertise from different research groups. These important discoveries are the result of a close collaboration between researchers from the VIB Department for Molecular Biomedical Research (UGent) and the VIB Department of Molecular and Developmental Genetics (K.U.Leuven).

Sooike Stoops | alfa
Further information:
http://www.vib.be

Further reports about: A20 Leuven Malt1 Treatment auto-immune immune system inflammation reactions

More articles from Life Sciences:

nachricht Designer cells: artificial enzyme can activate a gene switch
22.05.2018 | Universität Basel

nachricht Flow of cerebrospinal fluid regulates neural stem cell division
22.05.2018 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Designer cells: artificial enzyme can activate a gene switch

22.05.2018 | Life Sciences

PR of MCC: Carbon removal from atmosphere unavoidable for 1.5 degree target

22.05.2018 | Earth Sciences

Achema 2018: New camera system monitors distillation and helps save energy

22.05.2018 | Trade Fair News

VideoLinks
Science & Research
Overview of more VideoLinks >>>