Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


‘Telepathic’ genes recognise similarities in each other

Genes have the ability to recognise similarities in each other from a distance, without any proteins or other biological molecules aiding the process, according to new research published this week in the Journal of Physical Chemistry B. This discovery could explain how similar genes find each other and group together in order to perform key processes involved in the evolution of species.

This new study shows that genes – which are parts of double-stranded DNA with a double-helix structure containing a pattern of chemical bases - can recognise other genes with a similar pattern of chemical bases.

This ability to seek each other out could be the key to how genes identify one another and align with each other in order to begin the process of ‘homologous recombination’ – whereby two double-helix DNA molecules come together, break open, swap a section of genetic information, and then close themselves up again.

Recombination is an important process which plays a key role in evolution and natural selection, and is also central to the body’s ability to repair damaged DNA. Before now, scientists have not known exactly how suitable pairs of genes find each other in order for this process to begin.

... more about:
»DNA »DNA molecules »recognise »recombination

The authors of the new study carried out a series of experiments in order to test the theory, first developed in 2001 by two members of this team, that long pieces of identical double-stranded DNA could identify each other merely as a result of complementary patterns of electrical charges which they both carry. They wanted to verify that this could indeed occur without physical contact between the two molecules, or the facilitating presence of proteins.

Previous studies have suggested that proteins are involved in the recognition process when it occurs between short strands of DNA which only have about 10 pairs of chemical bases. This new research shows that much longer strands of DNA with hundreds of pairs of chemical bases seem able to recognise each other as a whole without protein involvement. According to the theory, this recognition mechanism is stronger the longer the genes are.

The researchers observed the behaviour of fluorescently tagged DNA molecules in a pure solution. They found that DNA molecules with identical patterns of chemical bases were approximately twice as likely to gather together than DNA molecules with different sequences.

Professor Alexei Kornyshev from Imperial College London, one of the study’s authors, explains the significance of the team’s results: “Seeing these identical DNA molecules seeking each other out in a crowd, without any external help, is very exciting indeed. This could provide a driving force for similar genes to begin the complex process of recombination without the help of proteins or other biological factors. Our team’s experimental results seem to support these expectations.”

Understanding the precise mechanism of the primary recognition stage of genetic recombination may shed light on how to avoid or minimise recombination errors in evolution, natural selection and DNA repair. This is important because such errors are believed to cause a number of genetically determined diseases including cancers and some forms of Alzheimer’s, as well as contributing to ageing. Understanding this mechanism is also essential for refining precise artificial recombination techniques for biotechnologies and gene therapies of the future.

The team is now working on a set of further experiments to determine exactly how these interactions work, including the predicted length dependence. In addition, further studies are needed to ascertain whether this interaction, discovered in a test tube, occurs in the highly complex environment of a living cell.

The study was carried out by researchers at Imperial College London and the National Institute of Health (NIH) in the USA. The work was funded in the UK by the EPSRC and supported by the NIH Institute of Child Health and Human Development.

Danielle Reeves | alfa
Further information:

Further reports about: DNA DNA molecules recognise recombination

More articles from Life Sciences:

nachricht International team discovers novel Alzheimer's disease risk gene among Icelanders
24.10.2016 | Baylor College of Medicine

nachricht New bacteria groups, and stunning diversity, discovered underground
24.10.2016 | DOE/Lawrence Berkeley National Laboratory

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

New method increases energy density in lithium batteries

24.10.2016 | Power and Electrical Engineering

International team discovers novel Alzheimer's disease risk gene among Icelanders

24.10.2016 | Life Sciences

New bacteria groups, and stunning diversity, discovered underground

24.10.2016 | Life Sciences

More VideoLinks >>>