Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers Identify A Means Of Controlling A Parasite That Kills And Eats Human Cells

18.01.2008
Researchers from the University of Virginia and the University of Vermont have discovered a means of inhibiting one of the world’s most voracious parasites. The study, published Friday, January 18 in PLoS Pathogens, targets a protein which aids the parasite in ingestion of immune cell corpses.

Entamoeba histolytica, which causes inflammation of the colon (colitis), plays dirty. It attacks and kills human immune cells in seconds. Then the parasite hides the evidence by eating the cells’ corpses. While doing so, it kills nearly 100,000 people each year.

The research team, led by Dr. William Petri, hypothesized that identifying molecules involved in the corpse ingestion might provide insight into how the amebae cause colitis in children.

The team identified a particular protein on the surface of the ameba called a kinase, PATMK. Using a special technique called RNA interference to inhibit the actions of this kinase, they prevented the ameba from eating dead cells.

... more about:
»ameba »parasite »prevent

“By blocking this kinase, we have for the first time prevented the ameba from colonizing and invading the gut,” said Dr. Petri. “This means that we are a step closer to preventing this disease, which wreaks havoc among children worldwide.”

“Infection and further invasion into the gut require the clearance of dead cells in order to prevent immune recognition of the damaged tissue,” says fellow researcher Douglas Boettner. “PATMK is the first individual member of a large family of proteins to be assigned a function related to the clearance of dying tissue during pathogenesis.”

This protein may be a pivotal vaccination target because these preliminary studies show that alterations in PATMK function reduces progression of amoebiasis in mice, Boettner added. “A vaccine that ultimately would prevent this amoeba from clearing the damaged host may attract helpful immune cells which may recognize and eliminate this infection.”

On a global basis, amebiasis affects approximately 50 million people each year, causing diarrhea, malnutrition and nearly 100,000 deaths.

This work shows how infection is dependent upon the ameba’s consumption of dead cells. By identifying the molecule that controls eating, scientists are one step closer to the ultimate goal of preventing disease caused by this parasite.

Andrew Hyde | alfa
Further information:
http://pathogens.plos.org

Further reports about: ameba parasite prevent

More articles from Life Sciences:

nachricht Tag it EASI – a new method for accurate protein analysis
19.06.2018 | Max-Planck-Institut für Biochemie

nachricht How to track and trace a protein: Nanosensors monitor intracellular deliveries
19.06.2018 | Universität Basel

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Overdosing on Calcium

Nano crystals impact stem cell fate during bone formation

Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

Im Focus: Photoexcited graphene puzzle solved

A boost for graphene-based light detectors

Light detection and control lies at the heart of many modern device applications, such as smartphone cameras. Using graphene as a light-sensitive material for...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Carbon nanotube optics provide optical-based quantum cryptography and quantum computing

19.06.2018 | Physics and Astronomy

How to track and trace a protein: Nanosensors monitor intracellular deliveries

19.06.2018 | Life Sciences

New material for splitting water

19.06.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>