Research at UCLA’s Jonsson Comprehensive Cancer Center has raised that question.
It has been known for decades that reactive oxygen species (ROS) - ions or very small molecules that include free radicals - damage cells. But much to their surprise, Jonsson Cancer Center researchers found that in Drosophila, the common fruit fly, moderately elevated levels of ROS are a good thing.
These small molecules act as an internal communicator, signaling certain blood precursor cells, or blood stem cells, to differentiate into immune-bolstering cells in reaction to a threat. After the progenitor cells differentiate, the ROS levels return to normal, ensuring the safety and survival of the mature blood cells, said Utpal Banerjee, a Jonsson Cancer Center researcher and senior author of the study.
The study is published in the Sept. 24, 2009 issue of the peer-reviewed journal Nature.
The new finding was launched when Banerjee and his team set out to discover why fruit flies had naturally occurring, slightly elevated levels of ROS in their blood cell precursors, which is atypical of most other precursor cells.
“Reducing levels of reactive oxygen is usually the goal, and what we found was surprising,” said Banerjee, professor and chairman of the molecular, cell, and developmental biology department at UCLA. “Most stem cells don’t want to be damaged, so they have very low ROS levels. We wanted to know why this was different in the cells that we were investigating.”
Banerjee discovered that when ROS was taken away in the blood stem cells, they failed to differentiate into the immune-bolstering cells, called macrophages. On the other hand, when levels of ROS were further increased by genetic means, the blood stem cells “differentiated like gang busters,” Banerjee said, making a large number of macrophages.
But how did this happen? The ROS, Banerjee said, acted as a signaling mechanism that kept the blood stem cells in a certain state – when levels rose, it was a message to the cell to differentiate.
The implications from the finding are several fold, Banerjee said. The blood stem cells are stress sensing cells, their function is to sense conditions that increase oxidative stress and react with an immune response. Keeping their ROS levels slightly elevated puts the cells on alert, sensitized and ready to respond to any threat quickly.
That sparked a question: If fruit fly blood stem cells and mammalian blood stem cells operate in the same way, is it a good thing for people to be taking antioxidants? Are antioxidants dulling the immune system and its ability to react to threats?
“On the one hand, it’s good to have antioxidants to reduce the amount of reactive oxygen in our body that causes DNA damage,” Banerjee said. “But if we find that those blood stem cells aren’t primed to respond because the ROS levels are reduced, that would not be a good thing. Our findings raise the possibility that wanton overdose of antioxidant products may in fact inhibit formation of cells participating in innate immune response.”
It is known that certain types of mammalian blood stem cells, called common myeloid progenitors, do have elevated levels of ROS, but it isn’t known whether those levels operate as messengers for differentiation. Studies of mammalian systems are needed to determine why ROS levels are elevated and what, if any, function that serves in the cell. It is interesting, however, that these types of blood progenitors in mammals also give rise to macrophages, Banerjee said.
“What we found is that the fruit fly keeps its own ROS levels in the blood stem cells slightly high for its own benefit,” Banerjee said. “We do not have any direct evidence that this is true in humans, but our results suggest that further studies are needed to investigate a possible signaling role for ROS in the differentiation of precursor cells in mammalian myeloid cell development and oxidative stress response.”
UCLA's Jonsson Comprehensive Cancer Center has more than 240 researchers and clinicians engaged in disease research, prevention, detection, control, treatment and education. One of the nation's largest comprehensive cancer centers, the Jonsson center is dedicated to promoting research and translating basic science into leading-edge clinical studies. In July 2009, the Jonsson Cancer Center was named among the top 12 cancer centers nationwide by U.S. News & World Report, a ranking it has held for 10 consecutive years.
New application for acoustics helps estimate marine life populations
16.01.2018 | University of California - San Diego
Unexpected environmental source of methane discovered
16.01.2018 | University of Washington Health Sciences/UW Medicine
What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...
For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.
Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...
At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.
No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...
Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.
Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...
The oceans are the largest global heat reservoir. As a result of man-made global warming, the temperature in the global climate system increases; around 90% of...
08.01.2018 | Event News
11.12.2017 | Event News
08.12.2017 | Event News
17.01.2018 | Ecology, The Environment and Conservation
17.01.2018 | Physics and Astronomy
17.01.2018 | Awards Funding