A yeast named Candida glabrata commonly occurs in humans, usually on our skin. It does little harm there. But if it enters the blood system, it can be directly life threatening to people with poor immune defense, such as cancer and AIDS patients.
"It can actually eat you up from the inside," says Jure Piškur, professor at the Department of Cell and Organism Biology at the Lund University.
Jure Piškur, together with a team of research colleagues, has studied the underlying reasons that this yeast can cause more and more infections in humans. The research team has discovered that Candida glabrata can mutate surprisingly rapidly. Instead of mutations occurring in individual genes, this yeast can mutate by reorganizing their chromosomes and make extra copies of large chromosome pieces.
The consequence of this is that Candida glabrata is becoming more and more resistant to fungicidal medicine. The present research report shows that a certain mini-chromosome can enable the yeast fungus to survive even if it is treated with nearly ten times the normal dose of the fungicide fluconazole.
"Our research now aims to identify the weak points in Candida glabrata so that we can develop effective medicine," says Jure Piškur.
Candida glabrata has become the second most common yeast pathogen in humans. It primarily causes irritation, in the genitals, for instance. Jure Piškur stresses that people whose immune defense is normal run very little risk of being affected by the life-threatening form of fungal infection in the blood system.
The most common type of fungus in humans is called Candida albicans and causes commonly occurring infections in women's genitals. This yeast fungus is relatively easy to treat with fungicides. But more and more often after the treatment Candida albicans is replaced with the more resistant Candida glabrata.
The research findings regarding Candida glabrata were recently presented in two scientific journals, PNAS and Nature Review Microbiology.
PNAS 2009 106:2688-2693; published online before print February 9, 2009, doi:10.1073/pnas.0809793106Fungal Pathogenesis: Varying for virulence
For more information, please contact Jure Piškur, phone: +46 (0)46 - 222 83 73 or Jure.Piskur@cob.lu.se
Pressofficer Lena Björk Blixt; Lena.Bjork_Blixt@kanslin.lu.se;+46-46 222 71 86Facts about chromosomes and genes:
Lena Björk Blixt | idw
Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery
20.01.2017 | GSI Helmholtzzentrum für Schwerionenforschung GmbH
Seeking structure with metagenome sequences
20.01.2017 | DOE/Joint Genome Institute
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
20.01.2017 | Awards Funding
20.01.2017 | Materials Sciences
20.01.2017 | Life Sciences