Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

How pufferfish meditate magnesium to survive

27.08.2013
The gene mechanism responsible for altering magnesium ion secretion in fish is uncovered by scientists at Tokyo Tech. The details are described in the August 2013 issue of Tokyo Institute of Technology Bulletin

The gene mechanism responsible for altering magnesium ion secretion in fish is uncovered by scientists at Tokyo Tech. The details are described in the August 2013 issue of Tokyo Institute of Technology Bulletin: http://www.titech.ac.jp/bulletin/


Fig. 1 The team used linear and cyclic block copolymers to create flower-shaped micelles. The cyclic-based micelles withstood considerably higher temperatures and salinity levels, and could have numerous applications in industry and green chemistry.


Hypothetical model for renal divalent ion excretion in marine teleost

Scientists at Tokyo Institute of Technology collaborate colleagues at Japan’s Shimonoseki Academy of Marine Science and Mayo Clinic College of Medicine, Minnasota, USA, to uncovered the molecular mechanisms behind Mg2+ secretion in fresh and seawater Takifugu pufferfish species.

The bodily functions of creatures that live in aquatic environments are affected by the presence of ions of different elements in the water. Bodies naturally absorb and retain ions as essential nutrients, but an excess of any one ion in the body can be damaging.

The magnesium ion Mg2+ is the second most abundant cation in seawater. Both freshwater and seawater fish maintain a certain level of Mg2+ in the plasma in their bodies, and it has long been known that seawater fish secrete Mg2+ into their urine in order to avoid an excess of absorbed Mg2+ from their surroundings. However, certain species of fish are capable of living in both salt and freshwater conditions, and how they alter Mg2+ secretion in their bodies accordingly is not well understood.

Now, Akira Kato and co-workers at Tokyo Institute of Technology, together with researchers from Japan’s Shimonoseki Academy of Marine Science and Mayo Clinic College of Medicine, Minnasota, USA, have uncovered the molecular mechanisms behind Mg2+ secretion in fresh and seawater Takifugu pufferfish species (1).

“For freshwater fish, Mg2+ is an important nutrient which should be retained if excess Mg2+ is not absorbed from food,” explains Kato. “Seawater contains around 30 times more Mg2+ than the blood of seawater fish. If seawater fish cannot excrete excess Mg2+, they face hypermagnesemia which causes failure of normal tissue functions in the nerves, muscles, and heart.”

Open genome databases enabled Kato and his team to prepare a list of pufferfish genes that have homology to any known Mg2+ transporting systems in bacteria, plants, and mammals. Through this mammoth task, they pinpointed a gene called Slc41a1 that encodes ion-carrier proteins in other species and bacteria. Gene expression analyses showed that Slc41a1 genes are highly expressed in the duct system of the kidneys in pufferfish.

The team then compared the renal and intestinal expressions of Slc41a1 in seawater pufferfish Takifugu rubripes and the closely related euryhaline pufferfish Takifugu obscurus in both seawater and freshwater environments.

“We discovered that Slc41a1 expression was up-regulated when the fish were moved from freshwater to seawater conditions,” explains Kato. Using immunohistochemistry techniques, the researchers proved that Slc41a1 is found in vacuoles (organelles) in the kidney and mediates Mg2+ movement from inside to outside cells. This secretion mechanism allows the excess ions to be flushed from the body in the urine.

“The molecular study of vacuolar Mg2+ secretion in the kidneys of seawater fish has just begun,” states Kato. “We need to identify other components that support the function of Mg2+ transporter gene Slc41a1. We also need to confirm if similar systems are generally used by many different organisms, or if this method of secretion has specifically evolved in fish.”

Further information:

Miwako Kato and Yukiko Tokida, Center for Public Information
Tokyo Institute of Technology, 2-12-1,
Ookayama, Meguro-ku, Tokyo 152-8550, Japan
E-mail: publication@jim.titech.ac.jp
URL: http://www.titech.ac.jp/english/
Tel: +81-3-5734-2975, Fax: +81-3-5734-3661
About Tokyo Institute of Technology
As one of Japan’s top universities, Tokyo Institute of Technology seeks to contribute to civilization, peace and prosperity in the world, and aims at developing global human capabilities par excellence through pioneering research and education in science and technology, including industrial and social management. To achieve this mission, we have an eye on educating highly moral students to acquire not only scientific expertise but also expertise in the liberal arts, and a balanced knowledge of the social sciences and humanities, all while researching deeply from basics to practice with academic mastery. Through these activities, we wish to contribute to global sustainability of the natural world and the support of human life.

Website: http://www.titech.ac.jp/english/

Journal information

1. Z. Islam et al. Identification and proximal tubular localization of the Mg2+ transporter, Slc41a1, in a seawater fish. Am J Physiol Regul Integr Comp Physiol 305 (2013).

doi: 10.1152/ajpregu.00507.2012

Adarsh Sandhu | Research asia research news
Further information:
http://www.titech.ac.jp/bulletin/
http://www.researchsea.com

More articles from Life Sciences:

nachricht Antimicrobial substances identified in Komodo dragon blood
23.02.2017 | American Chemical Society

nachricht New Mechanisms of Gene Inactivation may prevent Aging and Cancer
23.02.2017 | Leibniz-Institut für Alternsforschung - Fritz-Lipmann-Institut e.V. (FLI)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

From rocks in Colorado, evidence of a 'chaotic solar system'

23.02.2017 | Physics and Astronomy

'Quartz' crystals at the Earth's core power its magnetic field

23.02.2017 | Earth Sciences

Antimicrobial substances identified in Komodo dragon blood

23.02.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>