Using cutting-edge methods to peer into the hidden genetic underpinnings of the disabling and disfiguring disease, the research, published in Nature Genetics, further maps the as-yet unknown territories of psoriasis and psoriatic arthritis.
The findings could lead to new drug targets and tailored treatments for the skin disease, says James T. Elder, M.D., Ph.D., the Kirk D. Wuepper Professor of Molecular Genetic Dermatology and lead investigator on the study, which included researchers from the Department of Dermatology and School of Public Health.
“This is a hot topic in genetics these days,” Elder says. “Even when you add up all the genes that have been found around the world so far, they only account for about 40 percent of the genetic liability to psoriasis. The question among geneticists continues to be, ‘Where is the dark matter?’ ”
The new research builds on past work by the U-M team, whose discoveries have helped to unveil the hereditary factors of the disease and provide scientists with a better understanding of psoriasis’ relationship to other autoimmune diseases, such as Crohn’s disease, rheumatoid arthritis and lupus.
So far, research worldwide has linked 25 genes to psoriasis, which has a strong hereditary component. Including the new discoveries, Elder’s team was involved in finding more than half of them.
Two of the four new susceptibility loci – or “hotspots” – were strongly linked to psoriatic arthritis, a painful and destructive form of arthritis that affects about 1 in 4 psoriasis patients, Elder says.
The roughly 7.5 million Americans with psoriasis also have a higher risk of dying from related cardiovascular problems.
Once a full catalog of psoriasis genes has been identified, scientists hope to generate a “psoriasis gene profile” that can predict one’s risk of developing the disease and pave the way for innovative treatments. Current treatments, including different types of immunosuppressive agents, aren’t always effective and can cause serious side effects – though a new drug called Stelara (ustekinumab), which targets one of the genes they discovered, has been giving patients months-long relief, Elder says.
U-M Professor of Biostatistics Goncalo R. Abecasis, D. Phil, was instrumental in designing software and statistical methods to analyze more than 6 million genetic variants from more than 4,000 people.
“It was a pretty daunting task,” Abecasis says. “We looked in greater detail at genetic variation than is typical so that we can understand the biology behind psoriasis and build better drugs.”
Methodology: The U-M led, multi-center, international study analyzed data from two recent psoriasis genome-wide association studies involving more than 4,300 individuals, with and without the disease. Those findings were followed up in a three-stage replication study involving more than 8,700 people. The newly identified loci include one at NOS2, one at FBXL19, one near PSMA6-NFKBIA, and one near TRAF3IP2. U-M led the research in the discovery of three of the loci. The TRAF3IP2 locus was reported in a second paper to be published in the same issue of Nature Genetics, in which Elder’s collaborators from the University of Kiel in Germany took a leading role.
Additional authors: Philip E. Stuart, Rajan P. Nair, Trilokraj Tejasvi, Johann E. Gudjonsson, Jun Ding, Yun Li, Robert Ike, John J. Voorhees, University of Michigan; Eva Ellinghaus, Andre Franke, University of Kiel, Germany; Stephan Weidinger, Bernadette Eberlein, University of Munich, Germany; Christian Gieger, H. Erich Wichmann, Ludwig-Maximilians University, Germany; Manfred Kunz, University of Lübeck, Germany; Gerald G. Krueger, University of Utah; Anne M. Bowcock, Washington University at St. Louis; Ulrich Mrowietz, Michael Weichenthal, University of Kiel, Germany; Henry W. Lim, Henry Ford Hospital, Detroit; Proton Rahman, Memorial University (Canada); Dafna D.Gladman, University of Toronto, Canada.
Funding: The research was supported by grants from the National Institutes of Health, Ann Arbor Veterans Affairs Hospital, German Ministry of Education and Research, and the Canadian Institutes of Health Research.
Disclosure: U-M has filed for patent protection and is actively engaged in finding a commercial partner who can help bring the developments to market.
Reference: Nature Genetics, published online Oct. 17, 2010. Print publication pending.Resources:
Ian Demsky | Newswise Science News
Single-stranded DNA and RNA origami go live
15.12.2017 | Wyss Institute for Biologically Inspired Engineering at Harvard
New antbird species discovered in Peru by LSU ornithologists
15.12.2017 | Louisiana State University
DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.
Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...
MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.
Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...
Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
11.12.2017 | Event News
08.12.2017 | Event News
07.12.2017 | Event News
15.12.2017 | Power and Electrical Engineering
15.12.2017 | Materials Sciences
15.12.2017 | Life Sciences