The large EU project PROSPECTS is a collaborative research effort of leading European scientists in the Proteomics field. PROSPECTS now presents a number of breakthroughs in a series of articles comprising a "Special Issue" of the top journal of the field: Molecular & Cellular Proteomics.
Coordinated by Matthias Mann, director at the Max Planck Institute of Biochemistry (MPIB) in Martinsried near Munich, Germany, the scientists lay out their contribution to the future of proteomics with a powerful and versatile set of assay systems for characterizing proteome dynamics.
“Proteomics specification in time and space” (PROSPECTS) is a five year collaborative project that commenced early in 2008 and is funded by the Research Directorate of the European Commission under the 7th Research Framework Program. PROSPECTS brings together ten leading research groups from around Europe, as well as Thermo Fisher Scientific, a mass spectrometry instrument manufacturer and chromatography company.
The different groups seek new insights into the cellular function of proteins and their aberration during diseases. “We here present a perspective on how the proteomics field is moving beyond simply identifying proteins,” says Matthias Mann. “It now provides powerful tools for characterizing proteome dynamics and thereby creates a new level of proteomics research.” The "Special Issue" contains a series of 16 original research papers documenting the recent progress in all aspects of proteomic research achieved within PROSPECTS.Original publications
Anja Konschak | Max-Planck-Institut
Water forms 'spine of hydration' around DNA, group finds
26.05.2017 | Cornell University
How herpesviruses win the footrace against the immune system
26.05.2017 | Helmholtz-Zentrum für Infektionsforschung
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
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26.05.2017 | Life Sciences
26.05.2017 | Life Sciences
26.05.2017 | Physics and Astronomy