One of the reasons for premature birth could be inflammation in the amniotic fluid or the placenta caused by bacteria. The infection triggers labour far earlier than expected.
The study saw researchers looking at various factors linked to inflammation, known as markers, in the amniotic fluid of 83 women whose waters broke early or who went into labour prematurely, and of 15 women who had elective caesareans at full term.
"We found that the galectin-3 marker was much higher in women who were threatening preterm delivery and who had signs of infection in their amniotic fluid or placenta," says Christina Doverhag, a postgraduate student at the Department of Physiology at the Sahlgrenska Academy. "This hasn't been measured in the amniotic fluid before."
The researchers also wanted to investigate the role of free radicals in brain injury in children who were born prematurely or who suffered a lack of oxygen during birth. Free radicals damage the body's cells and are formed during inflammation, among other things.
"We studied two inflammation markers - galectin-3 and the enzyme NADPH-oxidase - in newborn mice. Our animal studies showed that galectin-3 can exacerbate brain injury, particularly in newborn males. In our other animal study we removed the NADPH-oxidase enzyme, and this led to greater injury and inflammation in some of the mice," says Doverhag, who draws the conclusion that both inflammation and galectin-3 play a significant role in brain damage in newborn children.This means that some medicines under development for the treatment of stroke and brain injury in adults, and which work in part by blocking the release of free radicals and NADPH-oxidase, are unlikely to be suitable for newborns with the same symptoms. They could, in fact, result in further injury.
"On the other hand, there is a common substance that can block galectin-3 and which is about to undergo further testing in the hunt for a treatment for brain injury in newborns," says Doverhag. "That substance is lactose, also known as milk sugar."However, further research is needed before concrete treatments become available.
The thesis has been successfully defended.For more information, please contact:
Title of thesis: Inflammation in experimental neonatal brain injury and in a clinical study of preterm birth; Involvement of galectin-3 and free radical formationJournal: Environmental Science and Technology.
Authors: Jerker Fick, Richard H Lindberg, Jari Parkkonen, Björn Arvidsson, Mats Tysklind, D G Joakim Larsson
Could this protein protect people against coronary artery disease?
17.11.2017 | University of North Carolina Health Care
Microbial resident enables beetles to feed on a leafy diet
17.11.2017 | Max-Planck-Institut für chemische Ökologie
The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.
Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...
Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.
That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...
Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.
During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....
The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.
Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...
Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...
15.11.2017 | Event News
15.11.2017 | Event News
30.10.2017 | Event News
17.11.2017 | Physics and Astronomy
17.11.2017 | Health and Medicine
17.11.2017 | Studies and Analyses