“When you develop, for example, nerve cells for transplantation, you always get a small contamination of immature stem cells”, explains Johan Jakobsson, head of research group at the Department of Experimental Medical Science.
The researchers have transplanted the stem cells into mice with Parkinson’s disease. The results are very promising: there are far fewer tumours and the cells that survive are the correct type of nerve cells. The technique uses a specially designed virus.
“We use the virus to genetically modify the cells, which means that we can see which ones we want and which ones we don’t want. You could say that we hijack one of the cell’s gene regulation systems, microRNA. The cell itself tells us when it is mature; it is black when it is immature and turns green when it has completed its development.”
It is relatively simple to isolate, cultivate, preserve and genetically modify stem cells. If transplanted into humans they could replace damaged tissue in the nervous system and support other cells that work to heal a brain injury.
“For us this is a major step. Previously tumours have always developed with this type of transplantation. Now we have shown that this can be avoided”, says Johan Jakobsson.
At Lund University collaborations are underway on stem cell therapy, for example, for Parkinson’s disease, diabetes, stroke, leukaemia and breast cancer. The research community has set the goal of making stem-cell based treatment effective and safe for at least one of the diseases within the next 10 years.
“Our technique could in theory be used for all these diseases”, says Johan Jakobsson. The next step is to conduct experiments on human cell lines.
This project is a collaboration within the Bagadilico research network.Johan Jakobsson; firstname.lastname@example.org;
Megan Grindley | idw
Single-stranded DNA and RNA origami go live
15.12.2017 | Wyss Institute for Biologically Inspired Engineering at Harvard
New antbird species discovered in Peru by LSU ornithologists
15.12.2017 | Louisiana State University
DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.
Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...
MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.
Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...
Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
11.12.2017 | Event News
08.12.2017 | Event News
07.12.2017 | Event News
15.12.2017 | Power and Electrical Engineering
15.12.2017 | Materials Sciences
15.12.2017 | Life Sciences