Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

NTU researchers complete the world's first in-depth study of the malaria parasite genome

08.02.2010
This breakthrough makes NTU's School of Biological Sciences a global leader in transcriptional profiling of malaria -- and better yet, could lead to a cure for malaria

Groundbreaking research done at Singapore's Nanyang Technological University's (NTU) School of Biological Sciences (SBS) could lead to the development of more potent drugs or a vaccine for malaria, which is transmitted to humans by infected mosquitoes and kills up to three million people each year.

Assistant Professor Zbynek Bozdech and his team of researchers, including graduate students and post-doctorals from SBS' Division of Genomics & Genetics, have scored a world first in successfully using transcriptional profiling to uncover hitherto unknown gene expression (activity) patterns in malaria.

The research team's breakthrough made the January 2010 edition of the top-ranked journal, Nature Biotechnology, which is a satellite publication of Nature, the world's leading peer-reviewed journal.

Transcriptional profiling is the measurement of the activity of thousands of genes at once, to create a global picture of cellular function. These profiles can, for example, distinguish between cells that are actively dividing, or show how the cells react to a particular treatment.

This outcome in infectious disease pathology could potentially be the decade's big breakthrough as it has yielded critical information about how the malaria parasite Plasmodium falciparum – the most deadly form of malaria – responds to existing compounds with curative potential.

The genome or the complete DNA content of the Plasmodium falciparum has about 5,300 genes. Up till now, scientists have a good understanding of the gene functions for only about half of the more than 5,000 genes. Using transcriptional profiling, Asst Prof Zbynek Bozdech's team has successfully uncovered the gene functions for almost the entire genome, with more than 90 percent of the gene functions from the previously unknown half now better understood.

"Drawing on our findings, pharmaceutical companies could explore ways to design a drug that targets the weakest link," said Asst Prof Bozdech of his research which was supported with S$900,000 in grants from Singapore's Ministry of Education and the National Medical Research Council. "We have predicted all the genes that could be used for a vaccine as well," he said.

Researchers at Germany's renowned institute for tropical diseases, the Bernhard Nocht Institute for Tropical Medicine, have validated the research findings, which are expected to provide exciting new insights into parasite biology.

"The successful NTU-BNI joint project has led to the creation of the world's first database to predict the functions of more than 2,500 genes of the malaria parasite previously unknown. The database would be useful to scientists around the world who are developing new vaccines and drugs," says Dr. Tim Gilberger, Head, Malaria Research at BNI.

Preventing malaria infection is important because resistance to anti-malarial drugs is a growing problem worldwide. There is currently no vaccine for malaria, which is widespread in poorer countries where it remains a hindrance to economic development. Also of growing concern to scientists is the confirmation of the first signs of resistance to the only affordable treatment left in the global medicine cabinet for malaria: Artemisinin.

In successfully using transcriptional profiling to study the behavior of the malaria parasite, NTU's researchers have ventured into the unknown and paved the way for future breakthroughs in healthcare.

"The wealth of new information arising from our extensive four-year study is a major contribution to the worldwide effort to better understand and treat malaria," said Prof Peter Rainer Preiser, Deputy Director of NTU's BioSciences Research Centre and a member of the NTU research team.

Hisham Hambari | EurekAlert!
Further information:
http://www.ntu.edu.sg

More articles from Life Sciences:

nachricht Rochester scientists discover gene controlling genetic recombination rates
23.04.2018 | University of Rochester

nachricht One step closer to reality
20.04.2018 | Max-Planck-Institut für Entwicklungsbiologie

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Molecules Brilliantly Illuminated

Physicists at the Laboratory for Attosecond Physics, which is jointly run by Ludwig-Maximilians-Universität and the Max Planck Institute of Quantum Optics, have developed a high-power laser system that generates ultrashort pulses of light covering a large share of the mid-infrared spectrum. The researchers envisage a wide range of applications for the technology – in the early diagnosis of cancer, for instance.

Molecules are the building blocks of life. Like all other organisms, we are made of them. They control our biorhythm, and they can also reflect our state of...

Im Focus: Spider silk key to new bone-fixing composite

University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.

Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.

Im Focus: Writing and deleting magnets with lasers

Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.

Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...

Im Focus: Gamma-ray flashes from plasma filaments

Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.

The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...

Im Focus: Basel researchers succeed in cultivating cartilage from stem cells

Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.

Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

IWOLIA: A conference bringing together German Industrie 4.0 and French Industrie du Futur

09.04.2018 | Event News

 
Latest News

Structured light and nanomaterials open new ways to tailor light at the nanoscale

23.04.2018 | Physics and Astronomy

On the shape of the 'petal' for the dissipation curve

23.04.2018 | Physics and Astronomy

Clean and Efficient – Fraunhofer ISE Presents Hydrogen Technologies at the HANNOVER MESSE 2018

23.04.2018 | Trade Fair News

VideoLinks
Science & Research
Overview of more VideoLinks >>>