Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New method can diagnose a feared form of cancer

21.03.2014

Pancreatic cancer is often detected at a late stage, which results in poor prognosis and limited treatment options.

Researchers at The University of Gothenburg in Sweden have now developed a method which identifies the cancer’s visible precursors with 97% certainty.

The method, which is expected to aid in the early discovery of the cancer as well as minimize the risk of unnecessary surgery, may be introduced in patient care within five years.

The poor prognosis for pancreatic cancer, where only 5 percent of the patients survive five years after the diagnosis, is due to the fact that the tumors often develop unnoticed, and rarely cause symptoms until they have spread to other organs. Recent studies, however, have shown that fluid-filled compartments in the pancreas, called cysts, may be precursors of the cancer.

... more about:
»Gothenburg »analyses »cysts »diagnosis »pancreatic »tumors

Cysts in the pancreas, which are found in every 10th person above the age of 70, and are also common in younger people, can be discovered with computed tomography (CT) or magnetic resonance imaging (MRI).

The problem is that imaging alone cannot determine which cysts are at risk for developing into cancer. Therefore, it often becomes necessary to puncture the cyst and look for tumor markers in the cyst fluid but not even these analyses are reliable.

Removing the cyst by surgery, with the knowledge that it may turn out to be completely benign, is also problematic since the operation is extensive, with considerable risks for the patient.

Researchers at The Sahlgrenska Academy, University of Gothenburg, have now developed a method which can predict with 97 percent certainty which pancreatic cysts constitute precursors to cancer. With this method, which detects the presence of mucus protein, mucins, in the cystic fluid, the researchers were able to reach the correct diagnosis in 77 of 79 cysts that were examined.

– This is an exceptionally good result for a diagnostic test, and we are very hopeful that the method will enable more instances of early discovery of pancreatic cancer, at a stage when the cancer can be treated or prevented. This approach may also minimize the risk of unnecessary operations on non-malignant cysts, said Karolina Jabbar, PhD student at The Sahlgrenska Academy and physician at The Sahlgrenska University Hospital.

The researchers have also tested the new method in order to analyze existing tumors and, with about 90 percent certainty, have been able to determine which tumors have already developed into cancers. This means that the method could also be used to determine which patients require immediate surgery, and when it is instead possible to wait and monitor the development of the cyst.

The method which has been used in the study is called proteomics, which means the analysis of the protein content of a tissue or fluid with the help of mass spectrometry . This method has thus far been used in research. But Professor Gunnar C. Hansson who, together with senior physician and Assistant Professor Riadh Sadik, initiated the study, is convinced that the proteomics will soon be introduced in health care.

– The technique has been developed, and we can now measure biomarkers both quickly and exactly. Moreover, the method requires minimal biomaterial, in this case 25 times less cyst fluid than conventional tumor marker analyses. I am certain that within five years the mass spectrometers will have moved into the hospital corridors, he said.

The article, Proteomic mucin profiling for the identification of cystic precursors of pancreatic cancer has been published in the respected cancer journal, Journal of the National Cancer Institute.

Link to the article: http://jnci.oxfordjournals.org/content/106/2/djt439.full?keytype=ref&ijkey=X...

Contact:
Karolina Jabbar, PhD student at The Sahlgrenska Academy, University of Gothenburg,
+46 31 786 38 61, karolina.sjoberg@medkem.gu.se

Gunnar C. Hansson, Professor at The Sahlgrenska Academy, University of Gothenburg,
+46 31 786 34 88, gunnar.hansson@medkem.gu.se

Weitere Informationen:

http://www.sahlgrenska.gu.se/english/news_and_events/news/News_Detail/?languageI...

Ulrika Lundin | idw - Informationsdienst Wissenschaft

Further reports about: Gothenburg analyses cysts diagnosis pancreatic tumors

More articles from Life Sciences:

nachricht Results Challenge Conventional Wisdom About Where the Brain Begins Processing Visual Information
04.03.2015 | Vanderbilt University

nachricht Sugar for synthetic cells
04.03.2015 | University of Freiburg

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Anzeige

Anzeige

Event News

70 Nobel laureates and 672 young scientists expected at Lindau

04.03.2015 | Event News

Registration open: 11th X-ray Forum for Customers of GE’s Digital Radiography and Industrial CT Inspection Technologies

04.03.2015 | Event News

ΣYSTEMS INTEGRATION in Finland focusses on high-tech printing

04.03.2015 | Event News

 
Latest News

Flexible and Functional – Prefabricated Façade Elements Simplify Building Renovation

04.03.2015 | Architecture and Construction

Emissions under control: comprehensive exhaust air analysis during laser processing of plastics

04.03.2015 | Ecology, The Environment and Conservation

Graphene, the wonder material, goes textile

04.03.2015 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>