Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Neuro-degeneration as a result of disbalanced biochemical equilibrium

06.06.2014

Recent insights of Prof. Anna von Mikecz, scientist at the IUF-Leibniz Research Institute for Environmental Medicine, shed new light on the development of protein aggregating diseases, e.g. Alzheimer’s, Parkinson’s and Huntington’s disease.

Anna von Mikecz, leader of the IUF group Influence of xenobiotics on the cell nucleus, focuses her research on the functional role of clumped, i.e. aggregated, proteins, also called amyloid, in the cell nucleus. As reported in her new scientific paper*, amyloid occurs also in healthy human cells and nuclei, and plays probably an important functional role.

Amyloids are formed by fibrillation of proteins. The main focus in the field of pharmacology lays on the pathological aspects of amyloids and countermeasures against neurodegenerative diseases today aim at the prevention of amyloid formation.

Prof. von Mikecz comments the assumption that amyloid formation is in general adverse, as follows: “This hypothesis is currently discussed controversially among scientists and it is becoming increasingly clear that we do not yet understand the molecular mechanisms of amyloid formation in the cell well enough.”A better understanding of the physiological and functional role of amyloids in the nucleus is a prerequisite for promising therapeutic interventions in neurodegenerative protein deposition diseases.”

The scientist’s results indicate that there is a tipping point for the adverse effect of amyloid in the nucleus, i.e. if a critical amount of amyloid in the nucleus is exceeded, harmful neuro-degenerative effects result.

Her research also shows that the amyloid equilibrium is disbalanced by exposure to xenobiotics such as certain nano-particles and heavy metals. The exposure leads to an increase in the amount of amyloid in the nucleus above the critical amount. This can be observed in vivo in animal studies as well as in vitro in cell cultures.

It is to be expected, that this new concept will facilitate the development of original diagnostic approaches, bring us significantly closer to effective countermeasures and also contribute to understanding the relationship between exposure to xenobiotics and the development of neuro-degenerative diseases.

*Anna von Mikecz (2014). Pathology and function of nuclear amyloid: protein homeostasis matters. Nucleus (open access, June 4th 2014)

Contact:
Dr. Mardas Daneshian
IUF
Phone: +49-(0)211-3389216
mardas.daneshian@iuf-duesseldorf.de

Weitere Informationen:

http://www.ncbi.nlm.nih.gov/pubmed/24896092
http://www.iuf-duesseldorf.com/von-mikecz-lab.html

Dr. Mardas Daneshian | idw - Informationsdienst Wissenschaft

Further reports about: IUF Pathology adverse biochemical diseases equilibrium exposure fibrillation neurodegenerative proteins

More articles from Life Sciences:

nachricht Modeling shockwaves through the brain
30.09.2014 | Massachusetts Institute of Technology

nachricht Risky metabolism: Risk-taking behaviour depends on metabolic rate and temperature in great tits
30.09.2014 | Max-Planck-Institut für Ornithologie

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Anzeige

Anzeige

Event News

BrainScaleS Conference: From Neurobiology to New Computer Architectures

25.09.2014 | Event News

17th European Health Forum Gastein: “Electing Health – The Europe We Want”

23.09.2014 | Event News

Future questions regarding data processing

22.09.2014 | Event News

 
Latest News

'Deadly diarrhea' rates nearly doubled in 10 years: Study

30.09.2014 | Studies and Analyses

Newborn Tropical Storm Phanfone triggers warnings in Northwestern Pacific

30.09.2014 | Earth Sciences

Modeling shockwaves through the brain

30.09.2014 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>