Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Neuro-degeneration as a result of disbalanced biochemical equilibrium

06.06.2014

Recent insights of Prof. Anna von Mikecz, scientist at the IUF-Leibniz Research Institute for Environmental Medicine, shed new light on the development of protein aggregating diseases, e.g. Alzheimer’s, Parkinson’s and Huntington’s disease.

Anna von Mikecz, leader of the IUF group Influence of xenobiotics on the cell nucleus, focuses her research on the functional role of clumped, i.e. aggregated, proteins, also called amyloid, in the cell nucleus. As reported in her new scientific paper*, amyloid occurs also in healthy human cells and nuclei, and plays probably an important functional role.

Amyloids are formed by fibrillation of proteins. The main focus in the field of pharmacology lays on the pathological aspects of amyloids and countermeasures against neurodegenerative diseases today aim at the prevention of amyloid formation.

Prof. von Mikecz comments the assumption that amyloid formation is in general adverse, as follows: “This hypothesis is currently discussed controversially among scientists and it is becoming increasingly clear that we do not yet understand the molecular mechanisms of amyloid formation in the cell well enough.”A better understanding of the physiological and functional role of amyloids in the nucleus is a prerequisite for promising therapeutic interventions in neurodegenerative protein deposition diseases.”

The scientist’s results indicate that there is a tipping point for the adverse effect of amyloid in the nucleus, i.e. if a critical amount of amyloid in the nucleus is exceeded, harmful neuro-degenerative effects result.

Her research also shows that the amyloid equilibrium is disbalanced by exposure to xenobiotics such as certain nano-particles and heavy metals. The exposure leads to an increase in the amount of amyloid in the nucleus above the critical amount. This can be observed in vivo in animal studies as well as in vitro in cell cultures.

It is to be expected, that this new concept will facilitate the development of original diagnostic approaches, bring us significantly closer to effective countermeasures and also contribute to understanding the relationship between exposure to xenobiotics and the development of neuro-degenerative diseases.

*Anna von Mikecz (2014). Pathology and function of nuclear amyloid: protein homeostasis matters. Nucleus (open access, June 4th 2014)

Contact:
Dr. Mardas Daneshian
IUF
Phone: +49-(0)211-3389216
mardas.daneshian@iuf-duesseldorf.de

Weitere Informationen:

http://www.ncbi.nlm.nih.gov/pubmed/24896092
http://www.iuf-duesseldorf.com/von-mikecz-lab.html

Dr. Mardas Daneshian | idw - Informationsdienst Wissenschaft

Further reports about: IUF Pathology adverse biochemical diseases equilibrium exposure fibrillation neurodegenerative proteins

More articles from Life Sciences:

nachricht Faster detection of pathogens in the lungs
24.06.2016 | Universität Zürich

nachricht How yeast cells regulate their fat balance
23.06.2016 | Goethe-Universität Frankfurt am Main

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First experimental quantum simulation of particle physics phenomena

Physicists in Innsbruck have realized the first quantum simulation of lattice gauge theories, building a bridge between high-energy theory and atomic physics. In the journal Nature, Rainer Blatt‘s and Peter Zoller’s research teams describe how they simulated the creation of elementary particle pairs out of the vacuum by using a quantum computer.

Elementary particles are the fundamental buildings blocks of matter, and their properties are described by the Standard Model of particle physics. The...

Im Focus: Is There Life On Mars?

Survivalist back from Space - 18 months on the outer skin of the ISS

A year and a half on the outer wall of the International Space Station ISS in altitude of 400 kilometers is a real challenge. Whether a primordial bacterium...

Im Focus: CWRU physicists deploy magnetic vortex to control electron spin

Potential technology for quantum computing, keener sensors

Researchers at Case Western Reserve University have developed a way to swiftly and precisely control electron spins at room temperature.

Im Focus: Physicists measured something new in the radioactive decay of neutrons

The experiment inspired theorists; future ones could reveal new physics

A physics experiment performed at the National Institute of Standards and Technology (NIST) has enhanced scientists' understanding of how free neutrons decay...

Im Focus: Discovery of gold nanocluster 'double' hints at other shape changing particles

New analysis approach brings two unique atomic structures into focus

Chemically the same, graphite and diamonds are as physically distinct as two minerals can be, one opaque and soft, the other translucent and hard. What makes...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ERES 2016: The largest conference in the European real estate industry

09.06.2016 | Event News

Networking 4.0: International Laser Technology Congress AKL’16 Shows New Ways of Cooperations

24.05.2016 | Event News

Challenges of rural labor markets

20.05.2016 | Event News

 
Latest News

Nanoscientists develop the 'ultimate discovery tool'

24.06.2016 | Materials Sciences

Russian physicists create a high-precision 'quantum ruler'

24.06.2016 | Physics and Astronomy

Hubble confirms new dark spot on Neptune

24.06.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>