Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Music Is the Engine of New Lab-on-a-chip Device

24.07.2009
Music, rather than electromechanical valves, can drive experimental samples through a lab-on-a-chip in a new system developed at the University of Michigan. This development could significantly simplify the process of conducting experiments in microfluidic devices.

Music, rather than electromechanical valves, can drive experimental samples through a lab-on-a-chip in a new system developed at the University of Michigan. This development could significantly simplify the process of conducting experiments in microfluidic devices.

A paper on the research will be published online in the Proceedings of the National Academy of Sciences the week of July 20.

A lab-on-a-chip, or microfluidic device, integrates multiple laboratory functions onto one chip just millimeters or centimeters in size. The devices allow researchers to experiment on tiny sample sizes, and also to simultaneously perform multiple experiments on the same material. There is hope that they could lead to instant home tests for illnesses, food contaminants and toxic gases, among other advances.

To do an experiment in a microfluidic device today, researchers often use dozens of air hoses, valves and electrical connections between the chip and a computer to move, mix and split pin-prick drops of fluid in the device's microscopic channels and divots.

"You quickly lose the advantage of a small microfluidic system," said Mark Burns, professor and chair of the Department of Chemical Engineering and a professor in the Department of Biomedical Engineering.

"You'd really like to see something the size of an iPhone that you could sneeze onto and it would tell you if you have the flu. What hasn't been developed for such a small system is the pneumatics---the mechanisms for moving chemicals and samples around on the device."

The U-M researchers use sound waves to drive a unique pneumatic system that does not require electromechanical valves. Instead, musical notes produce the air pressure to control droplets in the device. The U-M system requires only one "off-chip" connection.

"This system is a lot like fiberoptics, or cable television. Nobody's dragging 200 separate wires all over your house to power all those channels," Burns said. "There's one cable signal that gets decoded."

The system developed by Burns, chemical engineering doctoral student Sean Langelier, and their collaborators replaces these air hoses, valves and electrical connections with what are called resonance cavities. The resonance cavities are tubes of specific lengths that amplify particular musical notes.

These cavities are connected on one end to channels in the microfluidic device, and on the other end to a speaker, which is connected to a computer. The computer generates the notes, or chords. The resonance cavities amplify those notes and the sound waves push air through a hole in the resonance cavity to their assigned channel. The air then nudges the droplets in the microfluidic device along.

"Each resonance cavity on the device is designed to amplify a specific tone and turn it into a useful pressure," Langelier said. "If I play one note, one droplet moves. If I play a three-note chord, three move, and so on. And because the cavities don't communicate with each other, I can vary the strength of the individual notes within the chords to move a given drop faster or slower."

Burns describes the set-up as the reverse of a bell choir. Rather than ringing a bell to create sound waves in the air, which are heard as music, this system uses music to create sound waves in the device, which in turn, move the experimental droplets.

"I think this is a very clever system," Burns said. "It's a way to make the connections between the microfluidic world and the real world much simpler."

The new system is still external to the chip, but the researchers are working to make it smaller and incorporate it on a microfluidic device. That would be a step closer to a smartphone-sized home flu test.

The paper is called, "Acoustically-driven programmable liquid motion using resonance cavities." Other authors are U-M chemical engineering graduate students Dustin Chang and Ramsey Zeitoun. The research is funded by the National Institutes of Health and the National Science Foundation. The University is pursuing patent protection for the intellectual property, and is seeking commercialization partners to help bring the

For more information:

Mark Burns: www.engin.umich.edu/dept/cheme/people/burns.html
Sean Langelier: www.engin.umich.edu/dept/che/research/burns/people.html#Sean
Michigan Engineering:
The University of Michigan College of Engineering is ranked among the top engineering schools in the country. At more than $130 million annually, its engineering research budget is one of largest of any public university. Michigan Engineering is home to 11 academic departments and a National Science Foundation Engineering Research Center. The college plays a leading role in the Michigan Memorial Phoenix Energy Institute and hosts the world class Lurie Nanofabrication Facility. Find out more at www.engin.umich.edu/.

Nicole Casal Moore | Newswise Science News
Further information:
http://www.umich.edu

More articles from Life Sciences:

nachricht 'Lipid asymmetry' plays key role in activating immune cells
20.02.2018 | Biophysical Society

nachricht New printing technique uses cells and molecules to recreate biological structures
20.02.2018 | Queen Mary University of London

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: In best circles: First integrated circuit from self-assembled polymer

For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.

In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

Im Focus: Interference as a new method for cooling quantum devices

Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters

Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

'Lipid asymmetry' plays key role in activating immune cells

20.02.2018 | Life Sciences

MRI technique differentiates benign breast lesions from malignancies

20.02.2018 | Medical Engineering

Major discovery in controlling quantum states of single atoms

20.02.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>