Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Model Developed for Future Obesity Drug Testing

14.12.2011
Scientists have shown that over expression of a specific human protein in the brain of a transgenic mouse leads to overeating and excessive body weight gain.

Led by researchers at the University of Maryland School of Pharmacy, the mouse study may be ideal, they say, for testing new obesity controlling drugs and studies of the condition itself.

In the Dec. 13 online issue of the International Journal of Obesity, Wanli Smith, PhD, assistant professor in the Department of Pharmaceutical Sciences, and colleagues report a link between the protein synphilin-1 and obesity.

The School of Pharmacy researchers are collaborating with University of Maryland School of Medicine researchers to confirm if obese humans also express more synphilin-1 than others. Also, they are seeking collaboration with pharmaceutical companies.

“We have a new functional model that no one has done before,” says Smith. She explains that the pathogenesis of obesity is not fully understood by scientists. The mice also displayed some effects on high insulin levels and impaired glucose tolerance. Exploring the role of novel proteins in obesity may provide important insights into its causes and treatments.

The report pinpoints a previously unidentified role for synphilin-1 in controlling body weight. Synphilin-1 is a protein in cell plasma that was earlier shown to have implications with Parkinson’s disease symptoms. The University of Maryland team and others demonstrated recently that synphilin-1 may have protection effects in Parkinson’s disease models.

Steve Berberich | Newswise Science News
Further information:
http://www.umaryland.edu

Further reports about: Drug Delivery Parkinson Parkinson’s Disease Pharmacy synphilin-1

More articles from Life Sciences:

nachricht How cheetahs stay fit and healthy
24.03.2017 | Forschungsverbund Berlin e.V.

nachricht When Air is in Short Supply - Shedding light on plant stress reactions when oxygen runs short
23.03.2017 | Institut für Pflanzenbiochemie

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

NASA examines Peru's deadly rainfall

24.03.2017 | Earth Sciences

What does congenital Zika syndrome look like?

24.03.2017 | Health and Medicine

Steep rise of the Bernese Alps

24.03.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>