Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Mining bacterial genomes reveals valuable 'hidden' drugs

02.08.2010
A new tool to excavate bacterial genomes that potentially hide a rich array of pharmaceutical treasures has led to the discovery of a novel antibiotic. The study, reported in the August issue of Microbiology, could lead to new treatments for serious diseases that are rapidly acquiring multi-drug resistance.

Scientists from the University of Groningen in The Netherlands successfully used a 'genome mining' approach to find and activate a group of genes in the bacterium Streptomyces coelicolor. This resulted in the production of a new antibacterial compound that was effective against several bacterial strains, including Escherichia coli.

Streptomyces is a common soil bacterium that is well-known for its antibiotic-producing capabilities. In 2002, genomic sequencing of one Streptomyces species, S. coelicolor, revealed several groups of genes whose function was unknown. By digging deeper and removing a molecule that specifically inactivates one of the mystery gene groups, known as cpk, the researchers in this study were able to 'awaken' the genes, to find that they produced the new antibiotic, in addition to a bright yellow pigment.

This is the first time a genome mining approach to drug discovery has been successfully used in Streptomyces. "The strategy is a powerful and innovative way of searching for new antibiotic production capabilities in bacteria," said Dr Eriko Takano who led the study. "As bacterial infections previously considered as mild and easily curable are suddenly becoming lethal and completely unresponsive to all existing medication, it is crucial that new antibiotics are discovered at a sufficiently rapid rate," she said.

The same approach for 'awakening' new antibiotic production pathways could also be used to tap other micro-organisms, such as filamentous fungi, for sources of biologically active compounds. Aside from antibiotics, these compounds may include other antimicrobials or antitumour agents. "There are several thousand other uncharacterized groups of genes that have been found recently in microbial genome sequences. This opens up a rich treasure trove of new potential drugs for clinical use," explained Dr Takano.

Laura Udakis | EurekAlert!
Further information:
http://www.sgm.ac.uk

More articles from Life Sciences:

nachricht Fine organic particles in the atmosphere are more often solid glass beads than liquid oil droplets
21.04.2017 | Max-Planck-Institut für Chemie

nachricht Study overturns seminal research about the developing nervous system
21.04.2017 | University of California - Los Angeles Health Sciences

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

Im Focus: Quantum-physical Model System

Computer-assisted methods aid Heidelberg physicists in reproducing experiment with ultracold atoms

Two researchers at Heidelberg University have developed a model system that enables a better understanding of the processes in a quantum-physical experiment...

Im Focus: Glacier bacteria’s contribution to carbon cycling

Glaciers might seem rather inhospitable environments. However, they are home to a diverse and vibrant microbial community. It’s becoming increasingly clear that they play a bigger role in the carbon cycle than previously thought.

A new study, now published in the journal Nature Geoscience, shows how microbial communities in melting glaciers contribute to the Earth’s carbon cycle, a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

New quantum liquid crystals may play role in future of computers

21.04.2017 | Physics and Astronomy

A promising target for kidney fibrosis

21.04.2017 | Health and Medicine

Light rays from a supernova bent by the curvature of space-time around a galaxy

21.04.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>