Researchers at Heriot-Watt University and Plymouth Marine Laboratory (PML) in collaboration with Edinburgh based company Ingenza Ltd are searching for new enzymes for use as manufacturing tools in the pharmaceutical and agrochemical industries.
The research project, funded by the Biotechnology and Biological Sciences Research Council (BBSRC) and the Technology Strategy Board (TSB), uses biochemical techniques to identify potentially useful enzymes in microbes that are found in the sea.
This work brings important expertise from industry together with academic researchers. The value in this approach is to take specific knowledge and expertise in biochemistry and molecular biology, coupled with novel and diverse marine microbes, right through to high-yielding, scalable and economic manufacturing processes. These processes use enzyme catalysts from the marine microbes, which lead to greener and cleaner manufacturing methods.
Dr Robert Speight, from Ingenza Ltd, explained: "We are using biology in our chemical processes to come up with improved manufacturing routes. We are taking advantage of the natural diversity of marine organisms that has arisen through evolution in different environments and coupling that with high-tech screening systems. We are looking to find naturally occurring microbes that already have a built-in capacity to do the chemical reactions we want to perform in industry. There is every possibility of developing more efficient and sustainable manufacturing solutions - for pharmaceuticals and agrochemicals in particular - as a result of this search."
Microorganisms account for more than 95 per cent of ocean biomass but relatively little is really known about them and their potential applications. The research team's search is for industrially relevant enzymes which will reduce waste and increase productivity in the manufacture of drugs and agrochemicals. The enzymes they seek have the ability to convert compounds that would have previously been waste products in the manufacturing process, into the desired product, therefore increasing the efficiency of the process.
Professor Mark Keane, from Heriot-Watt University, said: "Our approach is to look for microbes which can promote the chemical reactions that we want to use in manufacturing. We then treat the microbes under conditions where they produce the key enzymes in higher yield, which we finally purify. The enzymes then undergo systematic testing to evaluate their activity, which enables us to pinpoint candidates that exhibit the best performance."
We are now identifying microbes with a type of enzyme called an amine oxidase. This could be key to cheaper, more efficient and sustainable process in the synthesis of valuable chemicals by both the pharmaceutical and agrochemical industries."
Commenting on the findings, BBSRC Chief Executive Professor Doug Kell, said: "Green and White biotechnologies are going to be an increasingly important part of the manufacturing landscape. Looking to biological systems that have been finely tuned by evolution to solve problems, rather than starting from scratch every time, might seem an obvious thing to do. It does however, in many cases, require the bringing together of particular niche expertise. The value of this collaboration is in the coincidence of knowledge and expertise from academia with the uniquely important business of synthesising a product on a large scale.
"What the outcomes of this project will offer us is the chance to have a significant impact on the sustainability of pharmaceutical and biochemicals production as we move from oil-based to photosynthesis-derived chemistry."
The research is featured in the summer issue of the new look Business, the BBSRC research highlights magazine.
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The Biotechnology and Biological Sciences Research Council (BBSRC) is the UK funding agency for research in the life sciences. Sponsored by Government, BBSRC annually invests around £450 million in a wide range of research that makes a significant contribution to the quality of life for UK citizens and supports a number of important industrial stakeholders including the agriculture, food, chemical, healthcare and pharmaceutical sectors. BBSRC carries out its mission by funding internationally competitive research, providing training in the biosciences, fostering opportunities for knowledge transfer and innovation and promoting interaction with the public and other stakeholders on issues of scientific interest in universities, centres and institutes.
The Babraham Institute, Institute for Animal Health, Institute of Food Research, John Innes Centre and Rothamsted Research are Institutes of BBSRC. The Institutes conduct long-term, mission-oriented research using specialist facilities. They have strong interactions with industry, Government departments and other end-users of their research.
Heriot-Watt University has a special place as a leading institution in science, technology and business and excelling as Scotland's most international university. The University provides more graduates per year across the physical sciences, mathematics, engineering and in the built environment than any other Scottish university
About Plymouth Marine Laboratory
PML is an independent, impartial provider of scientific research, contract services and advice for the marine environment, with a focus on understanding how marine ecosystems function and reducing uncertainty about the complex processes and structures that sustain life in the seas and their role in the Earth system.
As one of the world's first truly multidisciplinary marine research centres, PML delivers highly innovative research and solutions for national and international marine and coastal programmes. The research at PML is timely and highly relevant to UK and international societal needs and its research, development and training programmes have at their core the mission to contribute to issues concerned with understanding global change and the health and sustainability of marine ecosystems.
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