Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Map of substrate-kinase interactions may lead to more effective cancer drugs

28.03.2012
Later-stage cancers thrive by finding detours around roadblocks that cancer drugs put in their path, but a Purdue University biochemist is creating maps that will help drugmakers close more routes and develop better drugs.

Kinase enzymes deliver phosphates to cell proteins in a process called phosphorylation, switching a cellular function on or off. Irregularities in phosphorylation can lead to uncontrolled cell growth and are a hallmark of cancer.

Many successful cancer drugs are kinase inhibitors, which block the ability of a kinase to bind with a particular protein on the cell, stopping phosphorylation and the creation of cancer cells.

W. Andy Tao, a Purdue associate professor of biochemistry and member of the Purdue University Center for Cancer Research, said that in later stages of cancers, kinase-inhibiting drugs are ineffective because the kinases adapt, finding new protein targets and forming new cancer cells. He believes that creating maps of all the potential routes for cancer cell formation is a key to developing better cancer drugs.

"I would say that 99 percent of these drugs are effective for a few months in late-state cancers, and then the cancers develop resistance," said Tao, whose findings were published online early in the Proceedings of the National Academy of Sciences. "In the beginning, the cell cannot adjust and it dies. In later stages, the cells find a way. Cancer cells find a way to survive. You block one pathway, and they find another."

The kinase-protein maps Tao is creating identify kinases and the direct protein targets they phosphorylate. His method weeds out other proteins that are not direct targets, but are later phosphorylated as part of a cascade of reactions that begins when direct target proteins are phosphorylated.

Tao compared cells with and without kinases. The phosphoproteins present only when a kinase was present were considered possible targets. Further, the proteins were dephosphorylated, meaning the phosphate groups that had been added by kinases were removed.

The kinase was then re-introduced, and those proteins that accepted phosphate groups from the kinase were deemed direct targets of that kinase. With that information, drugmakers could tailor kinase-inhibiting drugs to ensure that the drug would stop kinases from reaching all potential targets, making the drugs more effective.

"If you understand the network, you can block all the pathways to cure the cancer," Tao said.
Tao's research findings focused on the SYK kinase, which is involved in leukemia and breast cancers. He plans to study other kinases, as well as mutated kinases, to understand whether they have different protein targets.

Tao collaborated with Robert Geahlen, a professor in medicinal chemistry and molecular pharmacology at Purdue. The National Institutes of Health funded the research.

Writer: Brian Wallheimer, 765-496-2050, bwallhei@purdue.edu
Source: Andy Tao, 765-494-9605, taow@purdue.edu
Ag Communications: (765) 494-2722;
Keith Robinson, robins89@purdue.edu
Agriculture News Page

Brian Wallheimer | EurekAlert!
Further information:
http://www.purdue.edu

More articles from Life Sciences:

nachricht Symbiotic bacteria: from hitchhiker to beetle bodyguard
28.04.2017 | Johannes Gutenberg-Universität Mainz

nachricht Nose2Brain – Better Therapy for Multiple Sclerosis
28.04.2017 | Fraunhofer-Institut für Grenzflächen- und Bioverfahrenstechnik IGB

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Fighting drug resistant tuberculosis – InfectoGnostics meets MYCO-NET² partners in Peru

28.04.2017 | Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

 
Latest News

Wireless power can drive tiny electronic devices in the GI tract

28.04.2017 | Medical Engineering

Ice cave in Transylvania yields window into region's past

28.04.2017 | Earth Sciences

Nose2Brain – Better Therapy for Multiple Sclerosis

28.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>