New, cost-effective therapy on the horizon. Magnesium improved blood clotting in case of a genetic defect of platelet development. An international team of scientists was able to demonstrate in mouse and patient studies, how magnesium affects the production of blood platelets and that the TRPM7 channel function plays a key role in this process. Scientists of the Rudolf Virchow Center and the Hospital of the University of Würzburg were primarily involved in this study. Their results were published in the current journal "Nature Communications".
A low platelet count (thrombocytopenia) prevents wound healing. People with a coagulation disorder can lose too much blood during otherwise harmless gum bleeding or other injuries.
Healthy platelets have an organized actin cytoskeleton (red), surrounded by microtubules (green). In Patients with TRPM7 channel defect, it's damaged, but can be restored with magnesium.
Research Group Nieswandt
Platelets (thrombocytes) are created in the bone marrow continuously from megakaryocytes. The molecular biological regulation of this cytoskeletal-controlled process has not been completely analyzed yet.
In this publication, researchers provided for the first time several independent lines of evidence that TRPM7 (Transient receptor potential melastatin-like 7) regulates the balance of magnesium in megakaryocytes. Magnesium itself is involved in many metabolic processes and therefore essential for the body.
Researchers manipulated the channel function of TRPM7 in megakaryocytes of mice and observed severe damages in the structure of platelets, the so-called cytoskeleton. Consequently platelets were inoperative. Patient samples where a TRPM7 channel dysfunction has been then identified, had a low concentration of magnesium (Mg2+) in their platelets.
The platelets showed an unusual size and shape, an abnormal structure and excessive vacuoles. Interestingly, the supplementation of magnesium to the platelets of mice or patients restored this defect completely in the test tube.
The study indicates that special attention should be paid on the number and size of platelets during the diagnosis of an imbalanced magnesium condition, as a platelet deficiency may be present. "If there is a genetic defect of TRPM7, administration of magnesium could be used as a relatively safe therapeutic intervention," hopes the leader of the study, Dr. Attila Braun.
The treatment would be cost effective and would have relatively few side effects. Further studies in animal models and patients (with altered TRPM7 channel function) have been initiated, in order to evaluate the efficacy and safety of magnesium as a therapeutic for this disease.
Researchers were particularly pleased about the direct correlation of mouse and patient data. "This was a huge advancement for the project", says Prof. Bernhard Nieswandt, who managed the project together with Dr. Attila Braun.
Platelets are small cellular components in the blood. They play an important role in coagulation. In case of an injury, they seal the vascular wall temporarily. If this function is impaired due to damaged platelets, immoderate bleeding may occur.
Dr. Daniela Diefenbacher | idw - Informationsdienst Wissenschaft
North and South Cooperation to Combat Tuberculosis
22.03.2018 | Universität Zürich
Researchers Discover New Anti-Cancer Protein
22.03.2018 | Universität Basel
An international team of researchers has discovered a new anti-cancer protein. The protein, called LHPP, prevents the uncontrolled proliferation of cancer cells in the liver. The researchers led by Prof. Michael N. Hall from the Biozentrum, University of Basel, report in “Nature” that LHPP can also serve as a biomarker for the diagnosis and prognosis of liver cancer.
The incidence of liver cancer, also known as hepatocellular carcinoma, is steadily increasing. In the last twenty years, the number of cases has almost doubled...
In just a few weeks from now, the Chinese space station Tiangong-1 will re-enter the Earth's atmosphere where it will to a large extent burn up. It is possible that some debris will reach the Earth's surface. Tiangong-1 is orbiting the Earth uncontrolled at a speed of approx. 29,000 km/h.Currently the prognosis relating to the time of impact currently lies within a window of several days. The scientists at Fraunhofer FHR have already been monitoring Tiangong-1 for a number of weeks with their TIRA system, one of the most powerful space observation radars in the world, with a view to supporting the German Space Situational Awareness Center and the ESA with their re-entry forecasts.
Following the loss of radio contact with Tiangong-1 in 2016 and due to the low orbital height, it is now inevitable that the Chinese space station will...
Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.
They are united in their passion for OLED (organic light emitting diodes) lighting with all of its unique facets and application possibilities. Thus experts in...
A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...
For the first time, an interdisciplinary team from the University of Basel has succeeded in integrating artificial organelles into the cells of live zebrafish embryos. This innovative approach using artificial organelles as cellular implants offers new potential in treating a range of diseases, as the authors report in an article published in Nature Communications.
In the cells of higher organisms, organelles such as the nucleus or mitochondria perform a range of complex functions necessary for life. In the networks of...
19.03.2018 | Event News
16.03.2018 | Event News
13.03.2018 | Event News
22.03.2018 | Trade Fair News
22.03.2018 | Earth Sciences
22.03.2018 | Earth Sciences