Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Magnesium treatment for genetic coagulation disorder

29.03.2016

New, cost-effective therapy on the horizon. Magnesium improved blood clotting in case of a genetic defect of platelet development. An international team of scientists was able to demonstrate in mouse and patient studies, how magnesium affects the production of blood platelets and that the TRPM7 channel function plays a key role in this process. Scientists of the Rudolf Virchow Center and the Hospital of the University of Würzburg were primarily involved in this study. Their results were published in the current journal "Nature Communications".

A low platelet count (thrombocytopenia) prevents wound healing. People with a coagulation disorder can lose too much blood during otherwise harmless gum bleeding or other injuries.


Healthy platelets have an organized actin cytoskeleton (red), surrounded by microtubules (green). In Patients with TRPM7 channel defect, it's damaged, but can be restored with magnesium.

Research Group Nieswandt


Microscope image of megakaryocytes (top right) in the process of platelet formation. The spherical swellings represent immature platelets. The DNA in the nucleus is dyed blue.

Research Group Nieswandt

Platelets (thrombocytes) are created in the bone marrow continuously from megakaryocytes. The molecular biological regulation of this cytoskeletal-controlled process has not been completely analyzed yet.

In this publication, researchers provided for the first time several independent lines of evidence that TRPM7 (Transient receptor potential melastatin-like 7) regulates the balance of magnesium in megakaryocytes. Magnesium itself is involved in many metabolic processes and therefore essential for the body.

Researchers manipulated the channel function of TRPM7 in megakaryocytes of mice and observed severe damages in the structure of platelets, the so-called cytoskeleton. Consequently platelets were inoperative. Patient samples where a TRPM7 channel dysfunction has been then identified, had a low concentration of magnesium (Mg2+) in their platelets.

The platelets showed an unusual size and shape, an abnormal structure and excessive vacuoles. Interestingly, the supplementation of magnesium to the platelets of mice or patients restored this defect completely in the test tube.

The study indicates that special attention should be paid on the number and size of platelets during the diagnosis of an imbalanced magnesium condition, as a platelet deficiency may be present. "If there is a genetic defect of TRPM7, administration of magnesium could be used as a relatively safe therapeutic intervention," hopes the leader of the study, Dr. Attila Braun.

The treatment would be cost effective and would have relatively few side effects. Further studies in animal models and patients (with altered TRPM7 channel function) have been initiated, in order to evaluate the efficacy and safety of magnesium as a therapeutic for this disease.

Researchers were particularly pleased about the direct correlation of mouse and patient data. "This was a huge advancement for the project", says Prof. Bernhard Nieswandt, who managed the project together with Dr. Attila Braun.

Platelets are small cellular components in the blood. They play an important role in coagulation. In case of an injury, they seal the vascular wall temporarily. If this function is impaired due to damaged platelets, immoderate bleeding may occur.

Weitere Informationen:

http://www.rudolf-virchow-zentrum.de/en/news/news/article/neue-kostenguenstige-t...

Dr. Daniela Diefenbacher | idw - Informationsdienst Wissenschaft

Further reports about: Biomedizin Magnesium bone marrow coagulation platelet wound healing

More articles from Life Sciences:

nachricht Researchers develop eco-friendly, 4-in-1 catalyst
25.04.2017 | Brown University

nachricht Transfecting cells gently – the LZH presents a GNOME prototype at the Labvolution 2017
25.04.2017 | Laser Zentrum Hannover e.V.

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

NASA's Fermi catches gamma-ray flashes from tropical storms

25.04.2017 | Physics and Astronomy

Researchers invent process to make sustainable rubber, plastics

25.04.2017 | Materials Sciences

Transfecting cells gently – the LZH presents a GNOME prototype at the Labvolution 2017

25.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>