Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Magnesium treatment for genetic coagulation disorder

29.03.2016

New, cost-effective therapy on the horizon. Magnesium improved blood clotting in case of a genetic defect of platelet development. An international team of scientists was able to demonstrate in mouse and patient studies, how magnesium affects the production of blood platelets and that the TRPM7 channel function plays a key role in this process. Scientists of the Rudolf Virchow Center and the Hospital of the University of Würzburg were primarily involved in this study. Their results were published in the current journal "Nature Communications".

A low platelet count (thrombocytopenia) prevents wound healing. People with a coagulation disorder can lose too much blood during otherwise harmless gum bleeding or other injuries.


Healthy platelets have an organized actin cytoskeleton (red), surrounded by microtubules (green). In Patients with TRPM7 channel defect, it's damaged, but can be restored with magnesium.

Research Group Nieswandt


Microscope image of megakaryocytes (top right) in the process of platelet formation. The spherical swellings represent immature platelets. The DNA in the nucleus is dyed blue.

Research Group Nieswandt

Platelets (thrombocytes) are created in the bone marrow continuously from megakaryocytes. The molecular biological regulation of this cytoskeletal-controlled process has not been completely analyzed yet.

In this publication, researchers provided for the first time several independent lines of evidence that TRPM7 (Transient receptor potential melastatin-like 7) regulates the balance of magnesium in megakaryocytes. Magnesium itself is involved in many metabolic processes and therefore essential for the body.

Researchers manipulated the channel function of TRPM7 in megakaryocytes of mice and observed severe damages in the structure of platelets, the so-called cytoskeleton. Consequently platelets were inoperative. Patient samples where a TRPM7 channel dysfunction has been then identified, had a low concentration of magnesium (Mg2+) in their platelets.

The platelets showed an unusual size and shape, an abnormal structure and excessive vacuoles. Interestingly, the supplementation of magnesium to the platelets of mice or patients restored this defect completely in the test tube.

The study indicates that special attention should be paid on the number and size of platelets during the diagnosis of an imbalanced magnesium condition, as a platelet deficiency may be present. "If there is a genetic defect of TRPM7, administration of magnesium could be used as a relatively safe therapeutic intervention," hopes the leader of the study, Dr. Attila Braun.

The treatment would be cost effective and would have relatively few side effects. Further studies in animal models and patients (with altered TRPM7 channel function) have been initiated, in order to evaluate the efficacy and safety of magnesium as a therapeutic for this disease.

Researchers were particularly pleased about the direct correlation of mouse and patient data. "This was a huge advancement for the project", says Prof. Bernhard Nieswandt, who managed the project together with Dr. Attila Braun.

Platelets are small cellular components in the blood. They play an important role in coagulation. In case of an injury, they seal the vascular wall temporarily. If this function is impaired due to damaged platelets, immoderate bleeding may occur.

Weitere Informationen:

http://www.rudolf-virchow-zentrum.de/en/news/news/article/neue-kostenguenstige-t...

Dr. Daniela Diefenbacher | idw - Informationsdienst Wissenschaft

Further reports about: Biomedizin Magnesium bone marrow coagulation platelet wound healing

More articles from Life Sciences:

nachricht Study shines light on brain cells that coordinate movement
26.06.2017 | University of Washington Health Sciences/UW Medicine

nachricht New insight into a central biological dogma on ion transport
26.06.2017 | Aarhus University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Study shines light on brain cells that coordinate movement

26.06.2017 | Life Sciences

Smooth propagation of spin waves using gold

26.06.2017 | Physics and Astronomy

Switchable DNA mini-machines store information

26.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>