Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Loss of gene function makes some prostate cancer cells more aggressive

03.02.2010
Prostate cancer cells are more likely to spread to other parts of the body if a specific gene quits functioning normally, according to new data from researchers at UT Southwestern Medical Center.
Certain prostate cancer cells can be held in check by the DAB2IP gene. The gene’s product, the DABIP protein, acts as scaffolding that prevents many other proteins involved in the progression of prostate cancer cells from over-activation. When those cells lose the DAB2IP protein, however, they break free and are able to metastasize, or spread, drastically increasing the risk of cancer progression in other organs as the cells travel through the bloodstream or lymph system.

The study in mice, published in the Jan. 11 issue of the Proceedings of the National Academy of Sciences, found that eliminating the DAB2IP scaffolding in human carcinoma cells caused them to change from epithelial cells to mesenchymal cells – a hallmark of metastatic cancer.
Cells undergoing an epithelial to mesenchymal transition (EMT) experience biological changes that enable them to move freely and spontaneously throughout the body,” said Dr. Jer-Tsong Hsieh, director of the Jean H. & John T. Walker Jr. Center for Research in Urologic Oncology at

UT Southwestern and the study’s senior author. “By restoring DAB2IP function in cancer cells in mice, we reversed their ability to change and metastasize.”

Dr. Hsieh said identifying the DAB2IP protein in human cells might serve as a biomarker, helping physicians identify patients who could have more aggressive, metastatic forms of prostate cancer.

EMT is known to play an important role in embryo implantation, embryogenesis and organ development, and tissue regeneration, as well as in cancer progression and metastasis. For cancer progression, EMT is believed to facilitate the migratory and invasive ability of cancer cells.

“Carcinoma cells undergo several changes that enable them to spread,” said Dr. Hsieh, also professor of urology. “The majority of human visceral tumors derived from carcinomas are primarily made up of epithelial cells. When they acquire mesenchymal phenotypes, they lose cell-to-cell adhesion and become more mobile throughout the body.”

In the current study, Dr. Hsieh and his team first shut down the DAB2IP gene expression in prostate epithelial cells in mice and found that the prostate cancers did indeed metastasize to lymph nodes and other organs in mice. When the researchers restored the DAB2IP genetic function to metastatic prostate cancer cells, the EMT process reversed, thereby inhibiting the cancer cells’ ability to spread.

“Based on the outcome of this paper, we believe the assessment of DAB2IP in these cancer cells can be a valuable prognostic biomarker for risk of the aggressiveness of certain prostate cancers,” said Dr. Daxing Xie, urology postdoctoral researcher and lead author of the study. “Further understanding of the DAB2IP function could also provide potential therapeutic strategies for treating prostate cancer.”

Other UT Southwestern researchers involved in this study were Crystal Gore and Michael Long, research technicians; Dr. Jun Liu, postdoctoral researcher; Rey-Chen Pong, senior research associate; Dr. Ralph Mason, professor of radiology; Dr. Guiyang Hao, postdoctoral researcher; Dr. Wareef Kabbani, assistant professor of pathology; Dr. Xiankai Sun, assistant professor of radiology in the Advanced Imaging Research Center; and Dr. David Boothman, professor of radiation oncology and pharmacology and associate director of translational research in the Harold C. Simmons Comprehensive Cancer Center.

The study was supported by the U.S. Army, the National Institutes of Health and the Department of Energy.

Visit www.utsouthwestern.org/cancercenter to learn more about UT Southwestern’s clinical services in cancer.

Media Contact: Katherine Morales
214-648-3404
katherine.morales@utsouthwestern.edu

Katherine Morales | EurekAlert!
Further information:
http://www.utsouthwestern.edu

More articles from Life Sciences:

nachricht Water world
20.11.2017 | Washington University in St. Louis

nachricht Carefully crafted light pulses control neuron activity
20.11.2017 | University of Illinois at Urbana-Champaign

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

Im Focus: Wrinkles give heat a jolt in pillared graphene

Rice University researchers test 3-D carbon nanostructures' thermal transport abilities

Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

Water world

20.11.2017 | Life Sciences

Less is more to produce top-notch 2D materials

20.11.2017 | Materials Sciences

Carefully crafted light pulses control neuron activity

20.11.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>