Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Lipids Help to Fight Leukemia

16.06.2014

T cells use a novel mechanism to fight leukemia.

They may recognize unique lipids produced by cancer cells and kill tumor cells expressing these lipid molecules. A study conducted by researchers at the University of Basel shows that a tumor-associated lipid stimulates specific T cells, which efficiently kill leukemia cells both in vitro and in animal models. The results have been published in the Journal of Experimental Medicine.

Leukemias are cancer diseases affecting blood cells . Acute leukemias prevent development of normal bold cells and thereby are severe life-threatening diseases. Current therapy for acute leukemias is based on chemotherapy that eradicates tumor cells followed by bone-marrow stem cell transplantation that reconstitutes the patient with healthy blood cells. In some cases, leukemia cells survive this treatment and start to re-grow. A major aim of many studies is finding novel and efficient ways to detect and eradicate leukemia cells before a second outbreak of the disease.

More punch against tumor cells

T lymphocytes are major contributors to fight against leukemias. T cells may recognize and become activated by tumor-specific protein antigens in some instances produced in large amounts only by tumor cells. These protein antigens are also called tumor-associated antigens (TAA) and stimulate specific T cells, which in turn kill leukemia cells. However, protein TAA accumulation can be drastically reduced by variant leukemia cells and some TAA may change their structure, thus preventing recognition by T cells and facilitating tumor immune evasion.

Prof. Gennaro De Libero and his team from the Department of Biomedicine at the University of Basel has identified a new approach that might help to make the immune system more efficient in recognizing leukemia cells. His research team is studying T cells that specifically recognize lipid antigens since several years. Together with colleagues in Italy, China and Singapore, the Swiss team has identified a new lipid that accumulates in leukemia cells and that stimulates specific T cell responses. The new lipid methyl-lysophosphatidic acid (mLPA) is very abundant in several forms of human leukemias and is the first example of a lipid TAA.

Therapeutic implications in human leukemia

The published study also shows that it is possible to isolate human T cells that specifically recognize and kill mLPA-expressing leukemia cells in in vitro tests. When these T cells were transplanted into mice, they also displayed great in vivo therapeutic efficacy against leukemia cells.

An important feature of mLPA is that differently from protein TAA, it does not change its structure, and remains abundant in leukemia cells. The Swiss team is now investigating, whether mLPA can be used to target leukemia cells in addition to protein TAA. This type of immunotherapy may be extremely beneficial in preventing relapses of the disease after chemotherapy and bone marrow transplantation. It opens new avenues to novel non-invasive cancer immunotherapies.

Original source
Marco Lepore, Claudia de Lalla, S. Ramanjaneyulu Gundimeda, Heiko Gsellinger, Michela Consonni, Claudio Garavaglia, Sebastiano Sansano, Francesco Piccolo, Andrea Scelfo, Daniel Häussinger, Daniela Montagna, Franco Locatelli, Chiara Bonini, Attilio Bondanza, Alessandra Forcina, Zhiyuan Li, Guanghui Ni, Fabio Ciceri, Paul Jenö, Chengfeng Xia, Lucia Mori, Paolo Dellabona, Giulia Casorati, and Gennaro De Libero
A novel self-lipid antigen targets human T cells against CDc+ leukemias
The Journal of Experimental Medicine (2014) | doi: 10.1084/jem.20140410

Further information
• Prof. Gennaro De Libero, University of Basel, Department of Biomedicine, phone: +41 61 265 23 65, email: gennaro.delibero@unibas.ch
• Dr. Lucia Mori, University of Basel, Department of Biomedicine, phone: +41 61 265 23 27, email: lucia.mori@unibas.ch

Weitere Informationen:

http://www.jem.org/cgi/doi/10.1084/jem.20140410 - Abstract

Reto Caluori | Universität Basel
Further information:
http://www.unibas.ch

Further reports about: Lipids Medicine chemotherapy diseases leukemia structure

More articles from Life Sciences:

nachricht Retracing the Roots of Fungal Symbioses
27.02.2015 | Lawrence Berkeley National Laboratory

nachricht Moving molecule writes letters
27.02.2015 | Technische Universitaet Muenchen

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Anzeige

Anzeige

Event News

European Geosciences Union meeting: programme online, provisional press conference topics

26.02.2015 | Event News

Round Table on Solar Energy Research

18.02.2015 | Event News

40th FEBS Congress 2015 – The Biochemical Basis of Life

09.02.2015 | Event News

 
Latest News

Researchers create self-reconstructive metal wire utilizing electric field trapping of gold nanoparticles

27.02.2015 | Power and Electrical Engineering

Climate-Change Clues From the Turtles of Tropical Wyoming

27.02.2015 | Ecology, The Environment and Conservation

Pockets of Calm Protect Molecules Around a Supermassive Black Hole

27.02.2015 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>