Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New Insights into the Signaling Network of the Vital Protein mTOR

22.02.2013
Many diseases are caused by malfunction of the mTOR signaling network. Accurate knowledge of network protagonists could therefore provide new therapeutic targets.

The research group of Prof. Michael N. Hall at the Biozentrum of the University of Basel has now identified a number of new mTOR-regulated proteins, including an enzyme that is essential for the production of the building blocks of DNA. Their results were recently published in the journal «Science».


The regulatory protein complex mTORC1 promotes CAD protein oligomerization (Green: CAD oligomers, Blue: DNA).
Image: University of Basel/Biozentrum

The protein mammalian target of rapamycin (mTOR) controls fundamentally important processes such as cell growth and metabolism. As the core component of two complexes, mTORC1 and mTORC2, it stimulates the production of proteins and fats, and ensures that cells have an adequate energy supply. Dysregulation of the finely-tuned mTOR signaling network is causally involved in the development of serious diseases such as cancer, cardiovascular diseases and diabetes. The search for previously unknown mTOR-regulated proteins could provide new approaches to treat these diseases.

Novel mTOR Target Proteins Identified

Because of the central role of mTOR in the cell, scientists suspect that many of the proteins and processes it controls remain to be discovered. By means of a very advanced technology, the so-called quantitative phosphoproteomics, the research group of Hall has now been able to identify more than 300 new mTOR target proteins which perform a wide range of tasks.

Detailed investigations showed that the mTORC1 stimulates, amongst others, the formation of nucleotides and thus controls the growth and proliferation of cells. Nucleotides are the building blocks of the genetic material and are manufactured in several steps from simple molecules. The first steps in the biosynthesis of nucleotides are mediated by the CAD enzyme. mTORC1 enhances the association of multiple CAD enzymes to form oligomers and thereby stimulates CAD activity and the production of nucleotides.

Many Details Unknown

Although we now understand well how mTOR acts, the current results show that there are still many details which are unknown. The comprehensive investigation of the mTOR-controlled signaling pathways and the effects of regulation deficiencies are enourmously important for the understanding of disease processes and the development of new therapeutic approaches. With their research, Hall and his team add another important piece to the mTOR puzzle.

Original article
Aaron M. Robitaille, Stefan Christen, Mitsugu Shimobayashi, Marion Cornu, Luca L. Fava, Suzette Moes, Cristina Prescianotto-Baschong, Uwe Sauer, Paul Jenoe, and Michael N. Hall (2013)
Quantitative Phosphoproteomics Reveal mTORC1 Activates de Novo Pyrimidine Synthesis

Science 1228771, Published online 21 February 2013 | doi: 10.1126/science.1228771

Contact
Prof. Michael N. Hall, University of Basel, Biozentrum, phone: +41 61 267 21 50, email: M.Hall@unibas.ch

Katrin Bühler | Universität Basel
Further information:
http://www.unibas.ch
http://dx.doi.org/10.1126/science.1228771
http://www.biozentrum.unibas.ch/research/groups-platforms/overview/unit/hall/

More articles from Life Sciences:

nachricht Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery
20.01.2017 | GSI Helmholtzzentrum für Schwerionenforschung GmbH

nachricht Seeking structure with metagenome sequences
20.01.2017 | DOE/Joint Genome Institute

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>