They studied the development of the lateral line organ in zebrafish, a sensory system found in fish and amphibians which serves to detect water flow and movements. Their findings show that two genes regulate cell organization within this epithelial tissue, which is found at different points along the fish body surface. Both genes also play a role in cancer development. (Journal of Cell Science, 10. February 10, 2009, doi: 10.1242/jcs.032102)*.
Organization of epithelial cell rosettes around zones of cell-cell contacts (red). Individual cell rosettes separate from the surrounding tissue and form neuromasts, sensors that are located at different points along the fish body surface, which detect water flow and movements. (Photo: David Hava/Copyright: MDC)
The study of David Hava, Dr. Ulrike Forster and Dr. Salim Abdelilah-Seyfried focused on the formation of cellular rosettes within an epithelial tissue and their separation from it. Normally, each cellular rosette gives rise to a neuromast, a sensor whose function it is to detect water flow movements.
The researchers have described for the first time the cellular machinery that is needed to form these epithelial cell rosettes within a compact migratory tissue.
Their research demonstrates that two genes have an important function in the formation of cellular rosettes: namely, to allow cells within the rosettes to adhere more strongly to each other than to the cells of the surrounding tissue. However, if one of the genes is lacking, the cells within the rosettes adhere to each other less strongly and the rosettes can no longer separate entirely from the surrounding tissue. As a consequence, fewer sensors develop.
Cell migration is not only significant for embryonic development but also in the development of cancer. Being a vertebrate, the tiny zebrafish shares many of the features of human systems which is why scientists use it as a model organism for studying vertebrate development and disease.Barbara Bachtler
Barbara Bachtler | Max-Delbrück-Centrum
Atomic-level motion may drive bacteria's ability to evade immune system defenses
24.04.2017 | Indiana University
Two-dimensional melting of hard spheres experimentally unravelled after 60 years
24.04.2017 | University of Oxford
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
20.04.2017 | Event News
18.04.2017 | Event News
03.04.2017 | Event News
24.04.2017 | Physics and Astronomy
24.04.2017 | Materials Sciences
24.04.2017 | Life Sciences