Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New infrared light may open new frontier in fighting cancer, Tay Sachs

01.09.2010
A "game-changing" technique using near infrared light enables scientists to look deeper into the guts of cells, potentially opening up a new frontier in the fights against cancer and many other diseases.

University of Central Florida chemists, led by Professor Kevin Belfield, used near infrared light and fluorescent dye to take pictures of cells and tumors deep within tissue. The probes specifically target lysosomes, which act as cells' thermostats and waste processors and which have been linked to a variety of diseases, including types of mental illnesses and cancers.

The probes can be adapted to search for certain proteins found in tumors, which means they someday may help doctors diagnose and potentially treat tumors.

"This is a game-changer," Belfield said. "Until now, there was no real way to study lysosomes because existing techniques have severe limitations. But the probe we developed is stable, which allows for longer periods of imaging."

Current imaging probes work for only a few minutes. They cannot penetrate deep tissue, are sensitive to pH levels and have poor water solubility. Belfield's technique gets around those problems by using near infrared light. Once researchers identified the correct light frequency, they took images of lysosomes for hours.

The new approach will allow researchers to see lysosomes at work and to piece together their role in diseases such as cancer and Tay-Sachs, a genetic disorder from which children typically die by age 4.

"We've come up with something that should make a huge difference in finding answers to some very complicated conditions," Belfield said.

Belfield's findings, which include comparisons to the only two existing probes on the market today, are published in this month's Journal of the American Chemical Society, one of the most highly ranked journals in chemistry.

Belfield published three other papers this summer looking at probes that were adapted to search for proteins found in tumors. Those articles were published in Organic and Biomolecular Chemistry and the Journal of Organic Chemistry.

The National Institutes of Health's National Institute for Biomedical Imaging and Bioengineering funded the project.

Belfield's team is continuing its research with NIH funding. The UCF researchers are working with the Sanford-Burnham Institute for Medical Research on the tests required before clinical studies can begin.

UCF Stands For Opportunity --The University of Central Florida is a metropolitan research university that ranks as the 3rd largest in the nation with 56,000 students. UCF's first classes were offered in 1968. The university offers impressive academic and research environments that power the region's economic development. UCF's culture of opportunity is driven by our diversity, Orlando environment, history of entrepreneurship and our youth, relevance and energy. For more information visit http://news.ucf.edu

Zenaida Gonzalez Kotala | EurekAlert!
Further information:
http://www.ucf.edu

More articles from Life Sciences:

nachricht The birth of a new protein
20.10.2017 | University of Arizona

nachricht Building New Moss Factories
20.10.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Terahertz spectroscopy goes nano

20.10.2017 | Information Technology

Strange but true: Turning a material upside down can sometimes make it softer

20.10.2017 | Materials Sciences

NRL clarifies valley polarization for electronic and optoelectronic technologies

20.10.2017 | Interdisciplinary Research

VideoLinks
B2B-VideoLinks
More VideoLinks >>>