Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Image or Mirror Image?

07.03.2012
Chiral recognition by femtosecond laser

It is not always easy to distinguish between images and mirror images of molecules, but this knowledge is important when one image of a molecule is a drug and the mirror image is toxic. One new approach to this may be chiral recognition in the gas phase.


This involves using synchrotron radiation (highly energetic photons from a particle accelerator) to eject electrons from the molecules and analyzing their trajectories. In the journal Angewandte Chemie, German researchers have now demonstrated that such experiments also work with a compact laser system.

The trick is to replace the individual high-energy photon with three laser photons that excite the molecule through intermediate levels until it releases an electron (this method is known as REMPI, Resonance-Enhanced Multi-Photon Ionization). “It is thus possible to eject electrons with less energetic but more intense light,” explains Thomas Baumert of the University of Kassel.

For the measurements, the light must be circularly polarized. What does this mean? “Ordinary” light consists of waves that oscillate in all spatial directions perpendicular to their direction of travel. If light is linearly polarized, the light waves oscillate exclusively in one plane. When light is circularly polarized, the light wave oscillates in a helical form, because its amplitude describes a circle around the axis of travel – either to the right or the left.

Molecules in the gas phase are randomly oriented and thus encounter the laser light from all possible angles; the ejected electrons also fly off in every possible direction as they leave the molecule. By using both a special configuration for measurement and special calculation processes, the team is able to determine the distribution of the angles of the electrons’ flight paths. In the case of linearly polarized light, the distribution is symmetrical.

“However, when the electrons are ejected by circularly polarized light, we find a distinct asymmetry to the angles at which the free electrons are found in relation to the laser beam,” reports Baumert. “This asymmetry is inverted if left circularly polarized light is used instead of right, an effect known as photoelectron circular dichroism. We observe the same effect when we keep the circular polarization the same but change from the “right handed” to the “left handed” structure of the chiral molecule being observed.”

The researchers were able to demonstrate this with the chiral compounds camphor and fenchone.

“This circular dichroism effect has previously only been observed with synchrotron radiation. In contrast, our procedure uses a compact laser system, so that this method is not limited to basic laboratory research but, because of the magnitude of the observed effects, may also find its way into analysis,” according to Baumert.

About the Author
Dr. Thomas Baumert has been Professor of Experimental Physics at the University of Kassel for over a decade. His research interests include femtosecond spectroscopy and ultrasound control of matter by means of tailored light fields.
Author: Thomas Baumert, Universität Kassel (Germany), http://www.physik.uni-kassel.de/de/484.html
Title: Circular Dichroism in the Photoelectron Angular Distributions of Camphor and Fenchone from Multiphoton Ionization with Femtosecond Laser Pulses

Angewandte Chemie International Edition, Permalink to the article: http://dx.doi.org/10.1002/anie.201109035

Thomas Baumert | Angewandte Chemie
Further information:
http://pressroom.angewandte.org.
http://www.physik.uni-kassel.de/de/484.html

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: In best circles: First integrated circuit from self-assembled polymer

For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.

In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

Im Focus: Interference as a new method for cooling quantum devices

Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters

Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Researchers invent tiny, light-powered wires to modulate brain's electrical signals

21.02.2018 | Life Sciences

The “Holy Grail” of peptide chemistry: Making peptide active agents available orally

21.02.2018 | Life Sciences

Atomic structure of ultrasound material not what anyone expected

21.02.2018 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>