According to the study's corresponding author, Dr. Wonhee Suh of the CHA University Stem Cell Institute, diabetes is often associated with impaired wound healing. While the therapeutic potential of transplanted EPCs has been demonstrated in animal models and in humans who have suffered stroke, myocardial infarction and peripheral artery disease, their effect in healing stubborn wounds has not been studied to the same degree.
"EPCs are involved in revascularization of injured tissue and tissue repair," said Dr. Suh. "Wounds associated with diabetes that resist healing are also associated with decreased peripheral blood flow and often resist current therapies. Normal wounds, without underlying pathological defects heal readily, but the healing deficiency of diabetic wounds can be attributed to a number of factors, including decreased production of growth factors and reduced revascularization.
The researchers, who transplanted EPCs into an experimental group of mice modeled with diabetes-associated wounds, but did not transplant EPCs into a control group, found that the EPCs "prompted wound healing and increased neovascularization" in the experimental group.
"The transplantation of EPCs derived from human umbilical blood cells accelerated wound closure in diabetic mice from the earliest point," said Dr. Suh. "Enhanced re-epithelialization made a great contribution in accelerating wound closure rate."
The researchers found that growth factors and cytokines (small proteins secreted by specific cells of the immune system) were "massively produced" at the wounded skin sites and contributed to the healing process.
"It remains unclear, however, which mechanism plays the dominant role in EPC-mediated tissue regeneration," commented Dr. Suh. "Further study is required since numerous studies have shown that the actual magnitude of EPC incorporation into the vasculature varies substantially from study to study."
"This experimental study opens the possibility of the future clinical use of endothelial progenitor cells derived from human cord blood in the treatment of diabetic wounds in humans" said Prof. Voltarelli, Professor of Clinical Medicine & Clinical Immunology at the University of Sao Pãulo, Brazil and section editor for Cell Transplantation . "Interestingly, it also shows that the culture medium used to grow the cells (conditioned media) has the same healing effect as the cells, so that it could be used as a cell-free form of treatment."Contact: Dr. Wonhee Suh, Department of Biomedical Sciences, College of Life Sciences, CHA University, CHA Stem Cell Institute, 606-16 Yeoksam 1-dong, Kangnam-gu, Seoul, 135-907, Korea
Tel: 82-2-3468-3668 Fax: 82-2-538-4102 Email: firstname.lastname@example.org
Citation: Kim, J. Y.; Song, S-H.; Kim, K. L.; Maeng, Y-S.; Im, J-E.; Yie, S. W.; Ahn, Y. K.; Kim, D-K.; Suh, W. Human Cord Blood-derived Endothelial Progenitor Cells and their Conditioned Media Exhibit Therapeutic Equivalence for Diabetic Wound Healing. Cell Transplant. 19(12):1635-1644; 2010.
The editorial offices for CELL TRANSPLANTATION are at the Center of Excellence for Aging and Brain Repair, College of Medicine, the University of South Florida and the Diabetes Research Institute, University of Miami Miller School of Medicine. Contact, David Eve, PhD. at email@example.com or Camillo Ricordi, MD at firstname.lastname@example.org
News Release by Randolph Fillmore, Florida Science Communications, www.sciencescribe.net
David Eve | EurekAlert!
Single-stranded DNA and RNA origami go live
15.12.2017 | Wyss Institute for Biologically Inspired Engineering at Harvard
New antbird species discovered in Peru by LSU ornithologists
15.12.2017 | Louisiana State University
DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.
Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...
MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.
Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...
Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
11.12.2017 | Event News
08.12.2017 | Event News
07.12.2017 | Event News
15.12.2017 | Power and Electrical Engineering
15.12.2017 | Materials Sciences
15.12.2017 | Life Sciences