Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Human cells build protein cages to trap invading Shigella

05.12.2011
Reseach presented at ASCB annual meeting

In research on the never-ending war between pathogen and host, scientists at the Pasteur Institute in Paris have discovered a novel defensive weapon, a cytoskeletal protein called septin, that humans cells deploy to cage the invading Shigella bacteria that cause potentially fatal human diarrhea, according to a presentation on Dec. 5, at the American Society for Cell Biology Annual Meeting in Denver.

Pascale Cossart, Ph.D., and Serge Mostowy, Ph.D., reported that the septin cages not only targeted the pathogens for degradation by autophagy, the cell's internal garbage disposal system, but also prevented the Shigella bacteria from spreading to other cells by impeding the pathogens' access to actin, a different component of the cell skeleton.

Shigella requires actin to rocket around the host cell before punching into an adjacent cell, said the Pasteur researchers, who made their discovery in human cells grown in culture in the laboratory.

First discovered in yeast as rings that pinch off dividing cells, septins are Guanosine-5'-triphosphate (GTP)-binding proteins that are integral to a cell's dynamic skeleton. Cossart, a Howard Hughes Medical Institute (HHMI) investigator, and Mostowy continue to investigate the properties of the individual septins, which total 14 in humans, to understand how they associate with other proteins as parts of complex nano-machines.

Before their studies revealed septin's new role in innate immunity, Cossart and Mostowy said that the cytoskeletal protein already was implicated in the pathogenesis of many human disorders including leukemia and colon cancer as well as Parkinson's and Alzheimer's diseases.

This research was supported by the Howard Hughes Medical Institute, European Research Council, Fondation Recherche Médicale, the Canadian Louis Pasteur Foundation, and Canadian Institutes of Health Research.

CONTACT:

Pascale Cossart, Ph.D.
Institut Pasteur
33-1-40-61-30-32
pcossart@pasteur.fr
John Fleischman
American Society for Cell Biology
jfleischman@ascb.org
513-929-4635
513-706-0212 (cell)
Cathy Yarbrough
American Society for Cell Biology
sciencematter@yahoo.com
858-243-1814
AUTHOR PRESENTS:
"Entrapment of Intracytosolic Bacteria by Septin Cage-Like Structures"
Sunday, Dec. 4, 2011
2 to 3:30 p.m.
Session: High-Order Actin-Based Structures
Presentation: 221
Board Number: B120
Exhibit Halls: A/B/E/F

John Fleischman | EurekAlert!
Further information:
http://www.ascb.org

More articles from Life Sciences:

nachricht Single-stranded DNA and RNA origami go live
15.12.2017 | Wyss Institute for Biologically Inspired Engineering at Harvard

nachricht New antbird species discovered in Peru by LSU ornithologists
15.12.2017 | Louisiana State University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First-of-its-kind chemical oscillator offers new level of molecular control

DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.

Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Engineers program tiny robots to move, think like insects

15.12.2017 | Power and Electrical Engineering

One in 5 materials chemistry papers may be wrong, study suggests

15.12.2017 | Materials Sciences

New antbird species discovered in Peru by LSU ornithologists

15.12.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>