Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Highway to Hydrogenase

19.01.2011
A New Way to Obtain the Hydrogenase Cofactor Azadithiolate

To obtain hydrogen as an energy-rich and environmentally "clean" fuel by an inexpensive, simple method without using expensive metal catalysts preoccupies scientists around the world. Hydrogenases, enzymes employed by organisms to yield hydrogen under anaerobic conditions, are being studied intensively as alternative systems.

A very popular research strategy is to build enzyme models that can then be modified to bring them closer to the ultimate goal of functioning even in the presence of some oxygen and not being impeded, or “poisoned”, by the hydrogen gas produced. Azadithiolate (S−–CH2–NH–CH2–S−) is one of the seven cofactors that make up an important part of such a hydrogenase catalyst.

Thomas Rauchfuss and his team at the University of Illinois at Urbana-Champaign developed a new approach to obtain this cofactor, which is described in the Short Communication published in the European Journal of Inorganic Chemistry.

This new approach employs organotitanium compounds, which are known to enable the synthesis of unusual ligands containing sulfur. A dithiolatotitanocene complex was first synthesized, demonstrating that titanocene stabilizes azadithiolate ligands. The next step was to transfer the azadithiolate ligand from the titanocene to a dinuclear iron center, which was successfully carried out with efficiency and good yield.

The importance of this new route to obtain diiron azadithiolato complexes is that it proceeds with high yield and does not require complicated reagents. In addition to describing the first synthesis and structural characterization of an azadithiolato complex not based on the diiron core, the scientists have succeeded in transferring the azadithiolate ligand to the diiron center, which enables further studies of this important cofactor.

Author: Thomas Rauchfuss, University of Illinois at Urbana-Champaign (USA), http://chemistry.illinois.edu/faculty/Thomas_Rauchfuss.html

Title: A New Route to Azadithiolato Complexes

European Journal of Inorganic Chemistry, Permalink to the article: http://dx.doi.org/10.1002/ejic.201001208

Thomas Rauchfuss | Wiley-VCH
Further information:
http://www.wiley-vch.de
http://chemistry.illinois.edu/faculty/Thomas_Rauchfuss.html

More articles from Life Sciences:

nachricht A novel socio-ecological approach helps identifying suitable wolf habitats
17.02.2017 | Universität Zürich

nachricht New, ultra-flexible probes form reliable, scar-free integration with the brain
16.02.2017 | University of Texas at Austin

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Switched-on DNA

20.02.2017 | Materials Sciences

Second cause of hidden hearing loss identified

20.02.2017 | Health and Medicine

Prospect for more effective treatment of nerve pain

20.02.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>