Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

High levels of uric acid may be associated with high blood pressure

28.08.2008
Reducing levels of uric acid in blood lowered blood pressure to normal in most teens in a study designed to investigate a possible link between blood pressure and the chemical, a waste product of the body's normal metabolism, said researchers at Baylor College of Medicine in a report that appears in the current issue of the Journal of the American Medical Association.

"If you reduce uric acid, at least in some patients, you may be able to reduce blood pressure," said Dr. Daniel Feig, associate professor of pediatrics-renal at BCM and chief of the pediatric hypertension clinics at Texas Children's Hospital. "This could be one way people develop hypertension and may allow us to develop new therapies."

Understanding how people develop high blood pressure gives scientists new tools for understanding the disorder and developing drugs to prevent and treat it.

Uric acid builds up when the body makes too much of it or fails to excrete it. It is a waste product resulting from the metabolism of food. Too much uric acid can cause gout, which occurs when uric acid crystals accumulate in the joints. In this study, researchers used allopurinol to reduce high uric acid levels. Allopurinol is usually used to treat gout, but Feig said its potential side effects rule it out as a treatment for high blood pressure.

In the JAMA study, Feig and his colleagues treated teens with newly diagnosed high blood pressure and elevated levels of uric acid in their blood with allopurinol. In the study, half of the 30 teen-agers with newly diagnosed high blood pressure and higher than normal levels of uric acid in their blood underwent treatment with allopurinol twice a day for four weeks. The other half received a placebo (an inactive drug) on the same schedule. They then went without either drug for two weeks before receiving the opposite treatment for another four weeks.

The treatment not only reduced uric acid levels, it also reduced blood pressure in most of the teens, said Feig. In fact, he said, blood pressures decreased to normal in 20 of the 30 teens when they were on allopurinol. By contrast, only 1 of the 30 teens had normal blood pressure when receiving placebo.

"This is far from being a reasonable therapeutic intervention for high blood pressure, but these findings indicate a first step in understanding the pathway of the disease," said Feig. "You cannot prevent a disease until you know the cause. This study is way of finding that out."

Studies in rats had indicated previously that high levels of uric acid could be associated with the development of high blood pressure through a proven pathway, said Feig. However, he and his colleagues needed to determine if this was true for humans as well.

"The antihypertensive therapies available to patients are well proven and safe," said Feig. "Currently available antihyperuricemic therapies (treatments that lower uric acid) are not safe enough to be used as first line therapy for most people with high blood pressure."

Side effects could include nausea, diarrhea, vomiting, liver problems and even a very rare, potentially life-threatening reaction known as Steven-Johnson syndrome. While only 1 in 3,000 people develop this problem, the risk is too great to prescribe the drug on a routine basis to people with high blood pressure, a problem that affects 30 to 35 percent of adults.

Currently available therapies are effective but are not solving the problem in everyone. Optimal blood pressures are achieved in only 40 percent of people who are treated for the problem. Understanding the cause of high blood pressure could lead to better treatments and even methods of prevention.

Animal studies indicate that early in the disease, the extra uric acid activates the renin angiotensin system of the body, shrinking key blood vessels and causing high blood pressure. Eventually, however, the small vessels in the kidney are permanently affected, making the blood pressure sensitive to salt or sodium. Too much salt causes the pressure to rise.

Glenna Picton | EurekAlert!
Further information:
http://www.bcm.edu
http://www.jama.com
http://www.bcm.edu/fromthelab

More articles from Life Sciences:

nachricht 'Y' a protein unicorn might matter in glaucoma
23.10.2017 | Georgia Institute of Technology

nachricht Microfluidics probe 'cholesterol' of the oil industry
23.10.2017 | Rice University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Salmonella as a tumour medication

HZI researchers developed a bacterial strain that can be used in cancer therapy

Salmonellae are dangerous pathogens that enter the body via contaminated food and can cause severe infections. But these bacteria are also known to target...

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

3rd Symposium on Driving Simulation

23.10.2017 | Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

 
Latest News

Microfluidics probe 'cholesterol' of the oil industry

23.10.2017 | Life Sciences

Gamma rays will reach beyond the limits of light

23.10.2017 | Physics and Astronomy

The end of pneumonia? New vaccine offers hope

23.10.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>