The concept was first shown in mice and advantages were documented. Online publication in JOURNAL FOR CLINICAL INVESTIGATION on 22 February 2013.
Engineered heart muscle tissue from parthenogenetic heart muscle cells
Faster, easier and more reliable – this is stem cell researcher Prof. Dr. Wolfram-Hubertus Zimmermann’s vision when thinking of heart repair with artificial cardiac cells or artificial cardiac tissue. Prof. Zimmermann, Director of the Department of Pharmacology at the University Medical Center Göttingen, Germany, and member of the Heart Research Center Göttingen (HRCG) and his team found a new and almost natural way of creating artificial heart-repair material.
The use of stem cells is indispensable for the clinical introduction of artificial cardiac tissue. The quest for Jack-of-all-trades cells is on. In Germany, researchers are looking particularly intensively into the potential of non-embryonic stem cells. Until recently, non-embryonic stem cells, which can be generated by unisexual reproduction or “virgin birth” (parthenogenesis) from unfertilized oocytes received little attention. These cells are called parthenogenetic stem cells (PS cells).
“We have shown for the first time that unfertilized oocytes are a promising starting material for the tissue engineering-based treatment of post-infarct heart failure” says Prof. Dr. Wolfram-Hubertus Zimmermann, senior author of the study: “What is important is that the method requires no embryos or genetic manipulations.”
Original publication: Michael Didié, Peter Christalla, Michael Rubart, Vijayakumar Muppala, Stephan Döker, Bernhard Unsöld, Thomas Rau, Thomas Eschenhagen, Alexander P Schwoerer, Heimo Ehmke, Udo Schumacher, Sigrid Fuchs, Claudia Lange, Alexander Becker, Tao Wen, John A Scherschel, Mark H Soonpaa, Tao Yang, Qiong Lin, Martin Zenke, Dong-Wook Han, Hans R. Schöler, Cornelia Ru-dolph, Doris Steinemann, Brigitte Schlegelberger, Steve Kattman, Alec Witty, Gor-don Keller, Loren J Field and Wolfram-Hubertus Zimmermann. Parthenogenetic Stem Cells for Tissue Engineered Heart Repair. J CLIN INVEST (2013) doi:10.1172/JCI66854.
“The road to clinical application in patients with heart failure is still long, and we need to ensure that patients are not exposed to intolerable risks”, says Prof. Zim-mermann. “On the other hand, cell-based tissue repair offers an exciting perspec-tive not only for the treatment of patients with heart failure but possibly also for the treatment of patients with other life-threatening diseases.”
Prof. Zimmermann envisions biobanks containing stem cell lines for therapeutic use. Model calculations permit the conclusion that 80 to 100 different PS cells would be sufficient to achieve tissue repair without the need for additional immune suppression in a population of an estimated 100 million.UNISEXUAL REPRODUCTION (PARTHENOGENESIS)
The Heart Research Center Göttingen (HRCG) was founded in 2010 from within the research focus “Heart Failure and Regeneration” at the University Medical Center Göttingen. Basic and clinical researchers are equally represented at the HRCG, which combines the collaborative efforts of the Heart Center Göttingen at the UMG, the Max Planck Institute (MPI) for Experimental Medicine, the MPI for Biophysical Chemistry, the MPI for Dynamics and Self-Organization and the German Primate Center (DPZ). The close collaboration between clinicians and basic researchers offers the unique opportunity to translate basic research results promptly into clinical practice. This objective is pursued by researchers of the HRCG as well as by partners at the German Center for Cardiovascular Research (Deutsches Zentrum für Herzkreislaufforschung, DZHK).FURTHER INFORMATION
Stefan Weller | idw
New Computer Model Could Explain how Simple Molecules Took First Step Toward Life
29.07.2015 | Brookhaven National Laboratory
Switch for building barrier in roots
29.07.2015 | The University of Tokyo
Researchers have developed an ultrafast light-emitting device that can flip on and off 90 billion times a second and could form the basis of optical computing.
Joint BioEnergy Institute study identifies bacterial protein that is key to protecting rice against bacterial blight
A bacterial signal that when recognized by rice plants enables the plants to resist a devastating blight disease has been identified by a multi-national team...
Researchers in the Cockrell School of Engineering at The University of Texas at Austin are one step closer to delivering smart windows with a new level of energy efficiency, engineering materials that allow windows to reveal light without transferring heat and, conversely, to block light while allowing heat transmission, as described in two new research papers.
By allowing indoor occupants to more precisely control the energy and sunlight passing through a window, the new materials could significantly reduce costs for...
Argonne scientists used Mira to identify and improve a new mechanism for eliminating friction, which fed into the development of a hybrid material that exhibited superlubricity at the macroscale for the first time. Argonne Leadership Computing Facility (ALCF) researchers helped enable the groundbreaking simulations by overcoming a performance bottleneck that doubled the speed of the team's code.
While reviewing the simulation results of a promising new lubricant material, Argonne researcher Sanket Deshmukh stumbled upon a phenomenon that had never been...
A NASA camera on the Deep Space Climate Observatory (DSCOVR) satellite has returned its first view of the entire sunlit side of Earth from one million miles away.
The color images of Earth from NASA's Earth Polychromatic Imaging Camera (EPIC) are generated by combining three separate images to create a...
23.07.2015 | Event News
10.07.2015 | Event News
25.06.2015 | Event News
29.07.2015 | Physics and Astronomy
29.07.2015 | Life Sciences
29.07.2015 | Awards Funding