The concept was first shown in mice and advantages were documented. Online publication in JOURNAL FOR CLINICAL INVESTIGATION on 22 February 2013.
Engineered heart muscle tissue from parthenogenetic heart muscle cells
Faster, easier and more reliable – this is stem cell researcher Prof. Dr. Wolfram-Hubertus Zimmermann’s vision when thinking of heart repair with artificial cardiac cells or artificial cardiac tissue. Prof. Zimmermann, Director of the Department of Pharmacology at the University Medical Center Göttingen, Germany, and member of the Heart Research Center Göttingen (HRCG) and his team found a new and almost natural way of creating artificial heart-repair material.
The use of stem cells is indispensable for the clinical introduction of artificial cardiac tissue. The quest for Jack-of-all-trades cells is on. In Germany, researchers are looking particularly intensively into the potential of non-embryonic stem cells. Until recently, non-embryonic stem cells, which can be generated by unisexual reproduction or “virgin birth” (parthenogenesis) from unfertilized oocytes received little attention. These cells are called parthenogenetic stem cells (PS cells).
“We have shown for the first time that unfertilized oocytes are a promising starting material for the tissue engineering-based treatment of post-infarct heart failure” says Prof. Dr. Wolfram-Hubertus Zimmermann, senior author of the study: “What is important is that the method requires no embryos or genetic manipulations.”
Original publication: Michael Didié, Peter Christalla, Michael Rubart, Vijayakumar Muppala, Stephan Döker, Bernhard Unsöld, Thomas Rau, Thomas Eschenhagen, Alexander P Schwoerer, Heimo Ehmke, Udo Schumacher, Sigrid Fuchs, Claudia Lange, Alexander Becker, Tao Wen, John A Scherschel, Mark H Soonpaa, Tao Yang, Qiong Lin, Martin Zenke, Dong-Wook Han, Hans R. Schöler, Cornelia Ru-dolph, Doris Steinemann, Brigitte Schlegelberger, Steve Kattman, Alec Witty, Gor-don Keller, Loren J Field and Wolfram-Hubertus Zimmermann. Parthenogenetic Stem Cells for Tissue Engineered Heart Repair. J CLIN INVEST (2013) doi:10.1172/JCI66854.
“The road to clinical application in patients with heart failure is still long, and we need to ensure that patients are not exposed to intolerable risks”, says Prof. Zim-mermann. “On the other hand, cell-based tissue repair offers an exciting perspec-tive not only for the treatment of patients with heart failure but possibly also for the treatment of patients with other life-threatening diseases.”
Prof. Zimmermann envisions biobanks containing stem cell lines for therapeutic use. Model calculations permit the conclusion that 80 to 100 different PS cells would be sufficient to achieve tissue repair without the need for additional immune suppression in a population of an estimated 100 million.UNISEXUAL REPRODUCTION (PARTHENOGENESIS)
The Heart Research Center Göttingen (HRCG) was founded in 2010 from within the research focus “Heart Failure and Regeneration” at the University Medical Center Göttingen. Basic and clinical researchers are equally represented at the HRCG, which combines the collaborative efforts of the Heart Center Göttingen at the UMG, the Max Planck Institute (MPI) for Experimental Medicine, the MPI for Biophysical Chemistry, the MPI for Dynamics and Self-Organization and the German Primate Center (DPZ). The close collaboration between clinicians and basic researchers offers the unique opportunity to translate basic research results promptly into clinical practice. This objective is pursued by researchers of the HRCG as well as by partners at the German Center for Cardiovascular Research (Deutsches Zentrum für Herzkreislaufforschung, DZHK).FURTHER INFORMATION
Stefan Weller | idw
New Model of T Cell Activation
27.05.2016 | Albert-Ludwigs-Universität Freiburg im Breisgau
Fungi – a promising source of chemical diversity
27.05.2016 | Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie - Hans-Knöll-Institut (HKI)
A biological and energy-efficient process, developed and patented by the University of Innsbruck, converts nitrogen compounds in wastewater treatment facilities into harmless atmospheric nitrogen gas. This innovative technology is now being refined and marketed jointly with the United States’ DC Water and Sewer Authority (DC Water). The largest DEMON®-system in a wastewater treatment plant is currently being built in Washington, DC.
The DEMON®-system was developed and patented by the University of Innsbruck 11 years ago. Today this successful technology has been implemented in about 70...
Permanent magnets are very important for technologies of the future like electromobility and renewable energy, and rare earth elements (REE) are necessary for their manufacture. The Fraunhofer Institute for Mechanics of Materials IWM in Freiburg, Germany, has now succeeded in identifying promising approaches and materials for new permanent magnets through use of an in-house simulation process based on high-throughput screening (HTS). The team was able to improve magnetic properties this way and at the same time replaced REE with elements that are less expensive and readily available. The results were published in the online technical journal “Scientific Reports”.
The starting point for IWM researchers Wolfgang Körner, Georg Krugel, and Christian Elsässer was a neodymium-iron-nitrogen compound based on a type of...
In the Beyond EUV project, the Fraunhofer Institutes for Laser Technology ILT in Aachen and for Applied Optics and Precision Engineering IOF in Jena are developing key technologies for the manufacture of a new generation of microchips using EUV radiation at a wavelength of 6.7 nm. The resulting structures are barely thicker than single atoms, and they make it possible to produce extremely integrated circuits for such items as wearables or mind-controlled prosthetic limbs.
In 1965 Gordon Moore formulated the law that came to be named after him, which states that the complexity of integrated circuits doubles every one to two...
Characterization of high-quality material reveals important details relevant to next generation nanoelectronic devices
Quantum mechanics is the field of physics governing the behavior of things on atomic scales, where things work very differently from our everyday world.
When current comes in discrete packages: Viennese scientists unravel the quantum properties of the carbon material graphene
In 2010 the Nobel Prize in physics was awarded for the discovery of the exceptional material graphene, which consists of a single layer of carbon atoms...
24.05.2016 | Event News
20.05.2016 | Event News
19.05.2016 | Event News
30.05.2016 | Power and Electrical Engineering
30.05.2016 | Ecology, The Environment and Conservation
30.05.2016 | Physics and Astronomy