Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Heart repair with unfertilized oocytes

First time worldwide: Research team at the University Medical Center Göttingen, Germany, grows heart repair tissue using stem cells from unfertilized oocytes.

The concept was first shown in mice and advantages were documented. Online publication in JOURNAL FOR CLINICAL INVESTIGATION on 22 February 2013.

Engineered heart muscle tissue from parthenogenetic heart muscle cells
Photo: umg

Faster, easier and more reliable – this is stem cell researcher Prof. Dr. Wolfram-Hubertus Zimmermann’s vision when thinking of heart repair with artificial cardiac cells or artificial cardiac tissue. Prof. Zimmermann, Director of the Department of Pharmacology at the University Medical Center Göttingen, Germany, and member of the Heart Research Center Göttingen (HRCG) and his team found a new and almost natural way of creating artificial heart-repair material.

The use of stem cells is indispensable for the clinical introduction of artificial cardiac tissue. The quest for Jack-of-all-trades cells is on. In Germany, researchers are looking particularly intensively into the potential of non-embryonic stem cells. Until recently, non-embryonic stem cells, which can be generated by unisexual reproduction or “virgin birth” (parthenogenesis) from unfertilized oocytes received little attention. These cells are called parthenogenetic stem cells (PS cells).

Researchers at the University Medical Center Göttingen (UMG), Germany, have now succeeded in growing heart tissue in the laboratory using stem cells generated from unfertilized murine oocytes. The heart tissue obtained, so-called Engineered Heart Muscle (EHM), beats spontaneously like natural heart tissue and can be used therapeutically in mice to repair heart attacks. These fundamental research results were published today, Friday, 22 February 2013, in the distinguished scientific JOURNAL FOR CLINICAL INVESTIGATION.

“We have shown for the first time that unfertilized oocytes are a promising starting material for the tissue engineering-based treatment of post-infarct heart failure” says Prof. Dr. Wolfram-Hubertus Zimmermann, senior author of the study: “What is important is that the method requires no embryos or genetic manipulations.”

Original publication: Michael Didié, Peter Christalla, Michael Rubart, Vijayakumar Muppala, Stephan Döker, Bernhard Unsöld, Thomas Rau, Thomas Eschenhagen, Alexander P Schwoerer, Heimo Ehmke, Udo Schumacher, Sigrid Fuchs, Claudia Lange, Alexander Becker, Tao Wen, John A Scherschel, Mark H Soonpaa, Tao Yang, Qiong Lin, Martin Zenke, Dong-Wook Han, Hans R. Schöler, Cornelia Ru-dolph, Doris Steinemann, Brigitte Schlegelberger, Steve Kattman, Alec Witty, Gor-don Keller, Loren J Field and Wolfram-Hubertus Zimmermann. Parthenogenetic Stem Cells for Tissue Engineered Heart Repair. J CLIN INVEST (2013) doi:10.1172/JCI66854.

In their work, the researchers scrutinized and documented the qualities and potentials of PS cells and produced the following results: PS cells share similar biologic properties with embryonic stem cells. PS cells are capable of generating functional heart muscle cells in the laboratory as well as in the body of mice. Moreover, PS cells can be used to produce engineered heart muscle in the laboratory. PS cells are immunologically simpler that other stem cells, which is very important for the broad application of engineered heart muscle for cardiac repair.
„Our investigations have shown: Artificial heart tissue from parthenogenetic stem cells causes no or easier-to-control rejection reactions even after implantation into genetically unrelated recipients. “This is a clear advantage over other stem cells”, says Dr. Michael Didié, first author of the publication and member of the Depart-ment of Pharmacology and the Department of Cardiology and Pneumology at UMG. This effect is due to the fact that the genetic material in uniparental parthe-notes is less variable than in opposite-sex embryos.
Subsequent investigations alone can show if the new concept, now shown for the first time in mice, is transferable to humans. The team around Prof. Zimmermann wants to test the therapeutic potential of parthenogenesis for patients. To do so, unfertilized human oocytes are needed. In Germany alone, 60,000 unfertilized oocytes are discarded annually, because they are unsuitable for in vitro fertilization procedures, according to statistics from the German Society for Reproductive Medicine. Thus, no additional oocyte donations are required for Prof. Zimmer-mann’s planned work, as merely the existing oocytes that are no longer needed can be used.

“The road to clinical application in patients with heart failure is still long, and we need to ensure that patients are not exposed to intolerable risks”, says Prof. Zim-mermann. “On the other hand, cell-based tissue repair offers an exciting perspec-tive not only for the treatment of patients with heart failure but possibly also for the treatment of patients with other life-threatening diseases.”

Prof. Zimmermann envisions biobanks containing stem cell lines for therapeutic use. Model calculations permit the conclusion that 80 to 100 different PS cells would be sufficient to achieve tissue repair without the need for additional immune suppression in a population of an estimated 100 million.

Natural parthenogenesis is a form of unisexual reproduction that can be found occasionally in the animal world. Viable offspring develop from unfertilized oocytes. Mammals, including humans, have lost the capacity of parthenogenesis. However, using a pharmacologic trick, mammalian oocytes, too, can be activated partheno-genetically in the laboratory. To do so, unfertilized oocytes are stimulated with an electrical or chemical stimulus alone to divide. An embryo cannot develop. The developing parthenotes can be used to obtain pluripotent stem cells.

The Heart Research Center Göttingen (HRCG) was founded in 2010 from within the research focus “Heart Failure and Regeneration” at the University Medical Center Göttingen. Basic and clinical researchers are equally represented at the HRCG, which combines the collaborative efforts of the Heart Center Göttingen at the UMG, the Max Planck Institute (MPI) for Experimental Medicine, the MPI for Biophysical Chemistry, the MPI for Dynamics and Self-Organization and the German Primate Center (DPZ). The close collaboration between clinicians and basic researchers offers the unique opportunity to translate basic research results promptly into clinical practice. This objective is pursued by researchers of the HRCG as well as by partners at the German Center for Cardiovascular Research (Deutsches Zentrum für Herzkreislaufforschung, DZHK).

University Medical Center Göttingen, Georg-August-University Göttingen
Department of Pharmacology
Prof. Dr. Wolfram-Hubertus Zimmermann
Robert-Koch-Str. 40, 37075 Göttingen
Telefone +49 (0)551 / 39-5781
Department of Pharmacology:

Stefan Weller | idw
Further information:

More articles from Life Sciences:

nachricht Novel mechanisms of action discovered for the skin cancer medication Imiquimod
21.10.2016 | Technische Universität München

nachricht Second research flight into zero gravity
21.10.2016 | Universität Zürich

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Resolving the mystery of preeclampsia

21.10.2016 | Health and Medicine

Stanford researchers create new special-purpose computer that may someday save us billions

21.10.2016 | Information Technology

From ancient fossils to future cars

21.10.2016 | Materials Sciences

More VideoLinks >>>