Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Haptoglobin as an early serum biomarker of virus-induced type 1 diabetes in rats

27.10.2010
Type 1 diabetes (T1D), formerly known as juvenile diabetes, is a multifactorial disease of complex etiology characterized by the autoimmune destruction of pancreatic beta cells.

In addition to genetic susceptibility, it is generally accepted that environmental factors play important roles in triggering disease, with virus infection having perhaps the strongest association.

Multiple viral infections including cytomegalovirus, mumps, rubella, enteroviruses, and parvovirus have all been associated with human T1D. Indeed, the effects of diverse viruses in triggering T1D may explain the heterogeneous nature of disease onset and kinetics in the general population.

The recent availability of novel immunomodulatory therapies that may preserve residual beta cell mass in new onset diabetics has generated a demand for noninvasive testable biomarkers that can identify the development of the autoreactive process before it becomes clinically apparent.

In the work published in the November issue of Experimental Biology and Medicine, Kruger and coworkers have utilized several well-established rat models of virus-induced T1D to search for serum biomarkers that occur early in disease development. Annie Kruger, working together with Rita Bortell and other colleagues at the University of Massachusetts Medical School, carried out the work. Dr. Kruger, a recent MD/PhD graduate, investigated the viral induction of autoimmune diabetes as part of her PhD thesis.

In a proteomics study of serum from rats treated with diabetogenic virus, the research team utilized 2D gel analysis and mass spectrometry and found increased levels of serum haptoglobin very early in the time course of diabetes induction. This result was confirmed by western and ELISA analyses, and sustained elevations of serum haptoglobin were generally predictive of ensuing diabetes. "Intriguingly," Dr. Bortell stated, "mutations in the human haptoglobin gene are associated with increased risk of diabetic complications such as retinopathy, nephropathy and cardiovascular disease. In our rat studies, however, haptoglobin was identified very early following virus infection, well prior to the development of diabetes or its complications, and thus may represent a biomarker for the pathogenesis of autoimmune diabetes as well."

To the researchers' knowledge, this is the first study that investigates T1D serum biomarkers found specifically in response to virus infection. Dr. Bortell said "As virus infections have historically been associated with the development of T1D in children, these rat models have particular relevance to the human disease. Reliably identifying children in the earliest phases of diabetes (pre-diabetes) would provide clinicians with a window of opportunity when pharmacotherapy could be most effective in slowing or halting the disease."

Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine, said "Kruger et al have identified haptoglobin as an early serum biomarker predictive of virus-induced T1D utilizing well-known rat models. This discovery, in conjunction with established markers of genetic susceptibility, should prove useful in identifying those children at risk for T1D."

Experimental Biology and Medicine is a journal dedicated to the publication of multidisciplinary and interdisciplinary research in the biomedical sciences. The journal was first established in 1903.

Experimental Biology and Medicine is the journal of the Society of Experimental Biology and Medicine. To learn about the benefits of society membership visit www.sebm.org. If you are interested in publishing in the journal please visit http://ebm.rsmjournals.com/.

Dr. Rita Bortell | EurekAlert!
Further information:
http://www.umassmed.edu

More articles from Life Sciences:

nachricht Multi-institutional collaboration uncovers how molecular machines assemble
02.12.2016 | Salk Institute

nachricht Fertilized egg cells trigger and monitor loss of sperm’s epigenetic memory
02.12.2016 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>