Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Changes in the gut bacteria protect against stroke

14.12.2012
Researchers at the University of Gothenburg, Sweden, and the Chalmers University of Technology, Sweden, demonstrate that an altered gut microbiota in humans is associated with symptomatic atherosclerosis and stroke. These findings are presented in a study published in Nature Communications on December 4.

The human body contains ten times more bacterial cells than human cells, most of which are found in the gut. These bacteria contain an enormous number of genes in addition to our host genome, and are collectively known as the gut metagenome.

Rapidly expanding field

How does the metagenome affect our health? This question is currently being addressed by researchers in the rapidly expanding field of metagenomic research. Several diseases have been linked to variations in the metagenome.

Researchers at Chalmers University of Technology and Sahlgrenska Academy, University of Gothenburg, now also show that changes in the gut metagenome can be linked to atherosclerosis and stroke.

Differences in gut microbiota

The researchers compared a group of stroke patients with a group of healthy subjects and found major differences in their gut microbiota. In particular, they showed that genes required for the production of carotenoids were more frequently found in gut microbiota from healthy subjects. The healthy subjects also had significantly higher levels of a certain carotenoid in the blood than the stroke survivors.

Affects disease states

Carotenoids are a type of antioxidant, and it has been claimed for many years that they protect against angina and stroke. Thus, the increased incidence of carotenoid-producing bacteria in the gut of healthy subjects may offer clues to explain how the gut metagenome affects disease states.

Carotenoids are marketed today as a dietary supplement. The market for them is huge, but clinical studies of their efficacy in protecting against angina and stroke have produced varying results.

Important health benefits

Jens Nielsen, Professor of Systems Biology at Chalmers, says that it may be preferable to take probiotics instead – for example dietary supplements containing types of bacteria that produce carotenoids.

“Our results indicate that long-term exposure to carotenoids, through production by the bacteria in the digestive system, has important health benefits. These results should make it possible to develop new probiotics. We think that the bacterial species in the probiotics would establish themselves as a permanent culture in the gut and have a long-term effect”.

Develop risk prognoses

“By examining the patient’s bacterial microbiota, we should also be able to develop risk prognoses for cardiovascular disease”, says Fredrik Bäckhed, Professor of Molecular Medicine at the University of Gothenburg,. ”It should be possible to provide completely new disease-prevention options”.

Close cooperation

The researchers have now started a company, Metabogen, to further develop their discoveries relating to the metagenome. Their success is based on close cooperation between engineers, microbiologists and doctors.

Jens Nielsen and Fredrik Bäckhed both agree that one of the challenges in the rapidly developing area of metagenomics is its multidisciplinary facets, requiring novel collaborations and merging of research fields.

The paper “Symptomatic atherosclerosis is associated with an altered gut metagenome” was published on December 4.

Contact:
Fredrik Bäckhed, Professor of Molecular Medicine at the Sahlgrenska Academy, University of Gothenburg, +46 31 342 78 33, fredrik.backhed@wlab.gu.se

Jens Nielsen, Professor of Systems Biology at Chalmers University of Technology, +46 70 243 66 18, nielsenj@chalmers.se

Fredrik Karlsson, research student in Systems Biology at Chalmers University of Technology, +46 31 772 38 86, fredrik.karlsson@chalmers.se

The research was funded by:
Knut and Alice Wallenberg Foundation, the Chalmers Foundation, Swedish Heart Lung Foundation, Torsten Söderberg’s Foundation, IngaBritt och Arne Lundbergs Foundation, AFA Insurances, the Swedish Research Council, and the Swedish Foundation for Strategic Research.

Helena Aaberg | idw
Further information:
http://www.gu.se
http://www.nature.com/ncomms/journal/v3/n12/full/ncomms2266.html
http://www.chalmers.se

More articles from Life Sciences:

nachricht Multi-institutional collaboration uncovers how molecular machines assemble
02.12.2016 | Salk Institute

nachricht Fertilized egg cells trigger and monitor loss of sperm’s epigenetic memory
02.12.2016 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>