Gold nanoparticles bring scientists closer to a treatment for cancer
Scientists at the University of Southampton have developed smart nanomaterials, which can disrupt the blood supply to cancerous tumours.
The team of researchers, led by Physics lecturer Dr Antonios Kanaras, showed that a small dose of gold nanoparticles can activate or inhibit genes that are involved in angiogenesis - a complex process responsible for the supply of oxygen and nutrients to most types of cancer.
"The peptide-functionalised gold nanoparticles that we synthesised are very effective in the deliberate activation or inhibition of angiogenic genes," said Dr Kanaras.
The team went a step further to control the degree of damage to the endothelial cells using laser illumination. Endothelial cells construct the interior of blood vessels and play a pivotal role in angiogenesis.
The researchers also found that the gold particles could be used as effective tools in cellular nanosurgery.
Dr Kanaras adds: "We have found that gold nanoparticles can have a dual role in cellular manipulation. Applying laser irradiation, we can use the nanoparticles either to destroy endothelial cells, as a measure to cut the blood supply to tumours, or to deliberately open up the cellular membrane in order to deliver a drug efficiently."
The researchers have published two related papers (NanoLett. 2011, 11 (3), 1358� Small 2011, 7, No. 3, 388�) with another one submitted for publication and four more planned throughout this year. Their major target is to develop a complete nanotechnology toolkit to manipulate angiogenesis.
Glenn Harris | EurekAlert!
The most recent press releases about innovation >>>
Die letzten 5 Focus-News des innovations-reports im Überblick:
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
Layered 2D material improves efficiency for solar cells and LEDs
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...