New experiments on mice show, that mouse mothers can protect their pups from developing type 1 diabetes by eating a gluten-free diet. According to preliminary studies by reseachers at the University of Copenhagen, the findings may apply to humans.
More than 1% of the Danish population has type 1 diabetes, one of the highest incidence rates in the world.
The mouse study adds more knowledge to a field that has been object for research many years.
New experiments on mice now show a correlation between the health of the pups and their mothers eating a gluten-free diet. Our hope is that the disease may be prevented through simple dietary changes, the researchers say.
"Preliminary tests show that a gluten-free diet in humans has a positive effect on children with newly diagnosed type 1 diabetes. We therefore hope that a gluten-free diet during pregnancy and lactation may be enough to protect high-risk children from developing diabetes later in life," says assistant professor Camilla Hartmann Friis Hansen from the Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences.
The findings have recently been published in the recognised journal Diabetes.
Findings from experiments on mice are not necessarily applicable to humans, but in this case we have grounds for optimism, says co-writer on the study professor Axel Kornerup from the Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences.
"Early intervention makes a lot of sense because type 1 diabetes develops early in life. We also know from existing experiments that a gluten-free diet has a beneficial effect on type 1 diabetes," he says.
Experiments of this type have been going on since 1999, originally initiated by Professor Karsten Buschard from the Bartholin Institute at Rigshospitalet in Copenhagen, another co-writer on the study.
"This new study beautifully substantiates our research into a gluten-free diet as an effective weapon against type 1 diabetes," Karsten Buschard explains.
The experiment showed that the diet changed the intestinal bacteria in both the mother and the pups. The intestinal flora plays an important role for the development of the immune system as well as the development of type 1 diabetes, and the study suggests that the protective effect of a gluten-free diet can be ascribed to certain intestinal bacteria. The advantage of the gluten-free diet is that the only side-effect seems to be the inconvenience of having to avoid gluten, but there is no certain evidence of the effect or side-effects.
"We have not been able to start a large-scale clinical test to either prove or disprove our hypothesis about the gluten-free diet," says Karsten Buschard.
Assistant Professor Camilla Hartmann Friis Hansen is hoping that it will be possible to continue the work.
"If we find out how gluten or certain intestinal bacteria modify the immune system and the beta-cell physiology, this knowledge can be used to develop new treatments," she says.
Professor Axel Kornerup Hansen
Cell: 30 66 34 86
Axel Kornerup Hansen | Eurek Alert!
Why some neurons “outsource” their cell body
21.04.2015 | Nationales Bernstein Netzwerk Computational Neuroscience
Bubbles dilemma solved after more than twenty years
21.04.2015 | University of Twente
Max Planck researcher Buhalqem Mamtimin determines how much nitrogen oxide is released into the atmosphere from agriculturally used oases.
In order to make statements about current and future air pollution, scientists use models which simulate the Earth’s atmosphere. A lot of information such as...
Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) and the University of Konstanz are working on storing and processing information on the level of single molecules to create the smallest possible components that will combine autonomously to form a circuit. As recently reported in the academic journal Advanced Science, the researchers can switch on the current flow through a single molecule for the first time with the help of light.
Dr. Artur Erbe, physicist at the HZDR, is convinced that in the future molecular electronics will open the door for novel and increasingly smaller – while also...
Cells of the vascular system of vertebrates can fuse with themselves. This process, which occurs when a blood vessel is no longer necessary and pruned, has now been described on the cellular level by Prof. Markus Affolter from the Biozentrum of the University of Basel. The findings of this study have been published in the journal “PLoS Biology”.
The vascular system is the supply network of the human organism and delivers oxygen and nutrients to the last corners of the body. So far, research on the...
Astronomers from Chalmers University of Technology have used the giant telescope Alma to reveal an extremely powerful magnetic field very close to a supermassive black hole in a distant galaxy
Astronomers from Chalmers University of Technology have used the giant telescope Alma to reveal an extremely powerful magnetic field very close to a...
A team of physicists from MPQ, Caltech, and ICFO proposes the combination of nano-photonics with ultracold atoms for simulating quantum many-body systems and creating new states of matter.
Ultracold atoms in the so-called optical lattices, that are generated by crosswise superposition of laser beams, have been proven to be one of the most...
13.04.2015 | Event News
25.03.2015 | Event News
19.03.2015 | Event News
21.04.2015 | Materials Sciences
21.04.2015 | Earth Sciences
21.04.2015 | Studies and Analyses