Reported in Nature Genetics, the findings offer a first-ever glimpse of the genetic basis for prostate cancer susceptibility in a non-European population.
Despite having the lowest rates of prostate cancer in the world, Asian countries have experienced a rapid rise in incidence of the disease, which ranks as one of the world’s most prevalent forms of cancer. In Japan, Western lifestyles and an aging society have led to surging prostate cancer rates, contributing to growing public interest in understanding associated genetic factors. Genome-wide association studies (GWAS), which involve scanning complete genomes for variations linked to a particular disease, have drawn attention as a powerful means to do this.
In their study, researchers at the RIKEN Center for Genomic Medicine (CGM) and the University of Tokyo compared such variations, known as single nucleotide polymorphisms (SNPs), in a population made up of 4,584 Japanese men with prostate cancer and 8,801 control subjects. Out of 31 SNPs linked to prostate cancer susceptibility in previous studies on European subjects, they found that 19 were also associated with susceptibility in the Japanese population. The remaining 12 SNPs showed no association, while five new genomic regions were identified as associated with prostate cancer which had not been reported in early studies on European populations.
While deepening our understanding of the genetic basis of prostate carcinogenesis, these findings, the first ever genome-wide data on prostate cancer in a non-European population, highlight variation in susceptibility among ethnic populations. A better understanding of such variation promises more accurate risk assessment, improvements in screening protocols and more effective clinical treatment.
For more information, please contact:Dr. Hidewaki Nakagawa
North and South Cooperation to Combat Tuberculosis
22.03.2018 | Universität Zürich
Researchers Discover New Anti-Cancer Protein
22.03.2018 | Universität Basel
An international team of researchers has discovered a new anti-cancer protein. The protein, called LHPP, prevents the uncontrolled proliferation of cancer cells in the liver. The researchers led by Prof. Michael N. Hall from the Biozentrum, University of Basel, report in “Nature” that LHPP can also serve as a biomarker for the diagnosis and prognosis of liver cancer.
The incidence of liver cancer, also known as hepatocellular carcinoma, is steadily increasing. In the last twenty years, the number of cases has almost doubled...
In just a few weeks from now, the Chinese space station Tiangong-1 will re-enter the Earth's atmosphere where it will to a large extent burn up. It is possible that some debris will reach the Earth's surface. Tiangong-1 is orbiting the Earth uncontrolled at a speed of approx. 29,000 km/h.Currently the prognosis relating to the time of impact currently lies within a window of several days. The scientists at Fraunhofer FHR have already been monitoring Tiangong-1 for a number of weeks with their TIRA system, one of the most powerful space observation radars in the world, with a view to supporting the German Space Situational Awareness Center and the ESA with their re-entry forecasts.
Following the loss of radio contact with Tiangong-1 in 2016 and due to the low orbital height, it is now inevitable that the Chinese space station will...
Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.
They are united in their passion for OLED (organic light emitting diodes) lighting with all of its unique facets and application possibilities. Thus experts in...
A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...
For the first time, an interdisciplinary team from the University of Basel has succeeded in integrating artificial organelles into the cells of live zebrafish embryos. This innovative approach using artificial organelles as cellular implants offers new potential in treating a range of diseases, as the authors report in an article published in Nature Communications.
In the cells of higher organisms, organelles such as the nucleus or mitochondria perform a range of complex functions necessary for life. In the networks of...
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