Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Genetic markers could predict prostate cancer in younger men

08.06.2010
Researchers link panel of genes to early onset prostate cancer

Prostate cancer has become more common in younger men, and it’s often more aggressive in these men. A new study from researchers at the University of Michigan Comprehensive Cancer Center has found that a series of genetic mutations could help detect this early onset prostate cancer.

Researchers believe that genetics and traditional screening methods could play a role in predicting the risk of prostate cancer in younger men.

“This is a potential opportunity to combine PSA testing with genetic markers to determine who has significant prostate cancer. It could be a combination of age and family history that could help us determine who should be tested with PSA and a panel of genetic markers,” says study author Kathleen Cooney, M.D., Frances and Victor Ginsberg Professor of Hematology/Oncology and division chief of hematology/oncology at the U-M Medical School.

Researchers looked for 14 different gene mutations in 754 men age 56 and younger with prostate cancer. The men were enrolled in the Prostate Cancer Genetics Project at U-M. Researchers also looked at 1,163 older men with prostate cancer and 2,713 men without prostate cancer.

The study, which was presented at the American Society of Clinical Oncology annual meeting, found that the younger men carried more of these genetic mutations. In addition, 30 percent of the younger men had aggressive prostate cancer and 41 percent of these men had at least one first-degree relative with prostate cancer.

“Early onset prostate cancer has a strong genetic component, which we saw in this study. The genetic variants we looked at here are likely not the best indicators. Our next step is to look more widely for common genetic variants among this group of men,” Cooney says.

The researchers continue to enroll men in this study. They will next look at the genome of a larger population of men with early onset prostate cancer to find common mutations that may be linked to the disease. For information, call the U-M Cancer AnswerLine at 800-865-1125.

Prostate cancer statistics: 192,280 Americans will be diagnosed with prostate cancer this year and 27,360 will die from the disease, according to the American Cancer Society

Additional authors: Claudia Salinas, Anna Ray, and Kimberly Zuhlke, from U-M; Yunfei Wang and Ethan Lange from University of North Carolina at Chapel Hill

Funding: Prostate Cancer Specialized Program of Research Excellence, National Cancer Institute, U-M Cancer Center

Reference: American Society of Clinical Oncology Annual Meeting, June 4-8, 2010, Chicago, Abstract No. 4502

Nicole Fawcett | EurekAlert!
Further information:
http://www.umich.edu

More articles from Life Sciences:

nachricht Not of Divided Mind
19.01.2017 | Hertie-Institut für klinische Hirnforschung (HIH)

nachricht CRISPR meets single-cell sequencing in new screening method
19.01.2017 | CeMM Forschungszentrum für Molekulare Medizin der Österreichischen Akademie der Wissenschaften

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

New Study Will Help Find the Best Locations for Thermal Power Stations in Iceland

19.01.2017 | Earth Sciences

Not of Divided Mind

19.01.2017 | Life Sciences

Molecule flash mob

19.01.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>