Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Genetic differences larger between populations in Northern Europe

27.10.2008
Researchers at Karolinska Institutet and Helsinki University have shown that the genetic differences appear larger between the populations in Northern Europe than within Central Europe.

The genetic distance is especially notable between Eastern and Western Finland. The study is published in the science journal PLoS One and is important for the understanding of genetic factors behind human diseases.

- When studying diseases and treatments, it is important to match the studied group with a similar control group. Otherwise the results could be overestimated, when they in fact just shows normal differences between for instance different part of a country, says Professor Juha Kere at Karolinska Institutet in Stockholm.

Human population genetic studies have recently gained a new powerful tool from the analysis of densely spaced single nucleotide polymorphisms (SNPs) across the whole genome. In this study, almost 250 000 such polymorphisms were used to analyze genetic differences between the Germans, British, Eastern and Western Finns and Swedes.

The Germans and British' are genetically close to each other, which also have been observed in other recently published studies. The genetic distances between the Swedes and Finns are somewhat larger. The researchers also found that the genetic difference between Eastern and Western Finland was substantial in a European scale. Even between Finnish counties there were clear differences

- The larger genetic distances in the north are caused by differences in population history. The northernmost parts of Europe were inhabited later than Central Europe and by fewer people, and have had smaller populations since then, says Päivi Lahermo, research team leader at Helsinki University.

Publication: "Genome-Wide Analysis of Single Nucleotide Polymorphisms Uncovers Population Structure in Northern Europe", Elina Salmela, Tuuli Lappalainen, Ingegerd Fransson, Peter M. Andersen, Karin Dahlman-Wright, Andreas Fiebig, Pertti Sistonen, Marja-Liisa Savontaus, Stefan Schreiber, Juha Kere, Päivi Lahermo, PLoS One, 24 oktober 2008

Further information, please contact:

Professor Juha Kere,
Department of Biosciences and Nutrition
Karolinska Institutet
Tel: +46 (0)73-4213550
E-mail: juha.kere@ki.se
Dr Päivi Lahermo
Institute for Molecular Medicine Finland
Helsinki University
Tel: +358407206315
E-mail: paivi.lahermo@helsinki.fi
Press Officer Katarina Sternudd
Karolinska Institutet
Tel: +46 (0)8-524 838 95
E-mail: katarina.sternudd@ki.se
Karolinska Institutet is one of the leading medical universities in Europe. Through research, education and information, Karolinska Institutet contributes to improving human health. Each year, the Nobel Assembly at Karolinska Institutet awards the Nobel Prize in Physiology or Medicine.

Katarina Sternudd | idw
Further information:
http://ki.se
http://dx.plos.org/10.1371/journal.pone.0003519
http://ki.se/pressimages

More articles from Life Sciences:

nachricht A novel socio-ecological approach helps identifying suitable wolf habitats
17.02.2017 | Universität Zürich

nachricht New, ultra-flexible probes form reliable, scar-free integration with the brain
16.02.2017 | University of Texas at Austin

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Switched-on DNA

20.02.2017 | Materials Sciences

Second cause of hidden hearing loss identified

20.02.2017 | Health and Medicine

Prospect for more effective treatment of nerve pain

20.02.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>